MAD2L1

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAD2L1 yw MAD2L1 a elwir hefyd yn Mitotic arrest deficient 2 like 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q27.

MAD2L1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DUJ, 1GO4, 1KLQ, 1S2H, 2QYF, 2V64, 2VFX, 3GMH
Dynodwyr
Cyfenwau	MAD2L1, HSMAD2, MAD2, MAD2 mitotic arrest deficient-like 1 (yeast), mitotic arrest deficient 2 like 1
Dynodwyr allanol	OMIM: 601467 HomoloGene: 1768 GeneCards: MAD2L1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • identical protein binding • protein C-terminus binding Cydrannau o'r gell • cytoplasm • cytosol • spindle pole • nuclear pore • Cromosom • perinuclear region of cytoplasm • mitotic spindle • chromosome, centromeric region • Cytosgerbwd • cnewyllyn cell • kinetochore • nucleoplasm • nuclear pore nuclear basket Prosesau biolegol • positive regulation of mitotic cell cycle spindle assembly checkpoint • GO:1903363 negative regulation of protein catabolic process • mitotic cell cycle checkpoint signaling • negative regulation of apoptotic process • Cellraniad • mitotic sister chromatid segregation • cell cycle • anaphase-promoting complex-dependent catabolic process • negative regulation of mitotic cell cycle • mitotic spindle assembly checkpoint signaling • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity • regulation of mitotic cell cycle phase transition • ubiquitin-dependent protein catabolic process • establishment of mitotic spindle orientation • establishment of centrosome localization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4085	n/a
Ensembl	ENSG00000164109	n/a
UniProt	Q13257	n/a
RefSeq (mRNA)	NM_002358	n/a
RefSeq (protein)	NP_002349	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAD2L1.

• MAD2
• HSMAD2

Llyfryddiaeth

• "Basis of catalytic assembly of the mitotic checkpoint complex. ". Nature. 2017. PMID 28102834.
• "MAD2γ, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors. ". Cell Cycle. 2016. PMID 27315568.
• "Mad2 overexpression is associated with high cell proliferation and reduced disease-free survival in primary gastrointestinal diffuse large B-cell lymphoma. ". Hematology. 2016. PMID 27077767.
• "Stable folding intermediates prevent fast interconversion between the closed and open states of Mad2 through its denatured state. ". Protein Eng Des Sel. 2016. PMID 26489879.
• "Structure of an intermediate conformer of the spindle checkpoint protein Mad2.". Proc Natl Acad Sci U S A. 2015. PMID 26305957.