MARK1

Protein sy'n cael ei godio yn y corff dynol gan y genyn MARK1 yw MARK1 a elwir hefyd yn Microtubule affinity regulating kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q41.

MARK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HAK, 3OSE
Dynodwyr
Cyfenwau	MARK1, MARK, Par-1c, Par1c, microtubule affinity regulating kinase 1
Dynodwyr allanol	OMIM: 606511 HomoloGene: 49552 GeneCards: MARK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • phosphatidylserine binding • metal ion binding • kinase activity • phosphatidic acid binding • protein serine/threonine kinase activity • tau-protein kinase activity • phosphatidylinositol-4,5-bisphosphate binding • ATP binding • magnesium ion binding • lipid binding • GO:0001948, GO:0016582 protein binding • tau protein binding Cydrannau o'r gell • cytoplasm • bilen • microtubule cytoskeleton • Cellbilen • Cytosgerbwd • dendrite • cell projection Prosesau biolegol • GO:0007243 intracellular signal transduction • phosphorylation • neuron migration • Wnt signaling pathway • protein phosphorylation • cytoskeleton organization • establishment of cell polarity • microtubule cytoskeleton organization • regulation of neuron projection development • GO:0035404 peptidyl-serine phosphorylation • regulation of dendrite development • establishment of mitochondrion localization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4139	n/a
Ensembl	ENSG00000116141	n/a
UniProt	Q9P0L2	n/a
RefSeq (mRNA)	NM_001286124 NM_001286126 NM_001286128 NM_001286129 NM_018650	n/a
RefSeq (protein)	NP_001273053 NP_001273055 NP_001273057 NP_001273058 NP_061120	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MARK1.

• MARK
• Par1c
• Par-1c

Llyfryddiaeth

• "Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase. ". Biochem J. 2017. PMID 27879374.
• "Mark/Par-1 marking the polarity of migrating neurons. ". Adv Exp Med Biol. 2014. PMID 24243102.
• "Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. ". BMC Neurosci. 2008. PMID 19090997.
• "Genome-wide association study in bipolar patients stratified by co-morbidity. ". PLoS One. 2011. PMID 22205951.
• "Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.". Hum Mol Genet. 2008. PMID 18492799.