MBD4

Protein sy'n cael ei godio yn y corff dynol gan y genyn MBD4 yw MBD4 a elwir hefyd yn Methyl-CpG binding domain 4, DNA glycosylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q21.3.

MBD4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2MOE, 3IHO, 4DK9, 4E9E, 4E9F, 4E9G, 4E9H, 4EA4, 4EA5, 4LG7, 4OFA, 4OFE, 4OFH, 5CHZ
Dynodwyr
Cyfenwau	MBD4, MED1, methyl-CpG binding domain 4, DNA glycosylase
Dynodwyr allanol	OMIM: 603574 HomoloGene: 2916 GeneCards: MBD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • satellite DNA binding • endodeoxyribonuclease activity • GO:0001948, GO:0016582 protein binding • catalytic activity • hydrolase activity • pyrimidine-specific mismatch base pair DNA N-glycosylase activity • DNA N-glycosylase activity Cydrannau o'r gell • chromatin • cnewyllyn cell • nucleoplasm • nuclear speck Prosesau biolegol • response to estradiol • depyrimidination • GO:0100026 DNA repair • cellular response to DNA damage stimulus • response to radiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8930	n/a
Ensembl	ENSG00000129071	n/a
UniProt	O95243	n/a
RefSeq (mRNA)	NM_001276270 NM_001276271 NM_001276272 NM_001276273 NM_003925	n/a
RefSeq (protein)	NP_001263199 NP_001263200 NP_001263201 NP_001263202 NP_003916	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MBD4.

• MED1

Llyfryddiaeth

• "Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA. ". J Mol Biol. 2012. PMID 22560993.
• "Crystal structure of the mismatch-specific thymine glycosylase domain of human methyl-CpG-binding protein MBD4. ". Biochem Biophys Res Commun. 2011. PMID 21820404.
• "Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. ". Oncotarget. 2015. PMID 26503472.
• "The MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population. ". Int J Gynecol Cancer. 2012. PMID 23027038.
• "Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.". Nucleic Acids Res. 2012. PMID 22848106.