ME1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ME1 yw ME1 a elwir hefyd yn Malic enzyme 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q14.2.

ME1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AW5, 3WJA
Dynodwyr
Cyfenwau	ME1, HUMNDME, MES, malic enzyme 1
Dynodwyr allanol	OMIM: 154250 HomoloGene: 134785 GeneCards: ME1
EC number	1.1.1.40
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • manganese ion binding • ADP binding • NAD binding • metal ion binding • NADP binding • electron transfer activity • malate dehydrogenase (decarboxylating) (NAD+) activity • oxidoreductase activity • oxaloacetate decarboxylase activity • malic enzyme activity • malate dehydrogenase (decarboxylating) (NADP+) activity Cydrannau o'r gell • cytoplasm • cytosol • mitocondria Prosesau biolegol • regulation of NADP metabolic process • protein tetramerization • NADP biosynthetic process • response to hormone • response to carbohydrate • malate metabolic process • regulation of lipid metabolic process • carbohydrate metabolic process • electron transport chain • pyruvate metabolic process • nucleotide biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4199	n/a
Ensembl	ENSG00000065833	n/a
UniProt	P48163	n/a
RefSeq (mRNA)	NM_002395	n/a
RefSeq (protein)	NP_002386	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ME1.

• MES
• HUMNDME

Llyfryddiaeth

• "Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. ". J Biol Chem. 2017. PMID 28848047.
• "Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma. ". Tumour Biol. 2015. PMID 25753478.
• "Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme. ". PLoS One. 2012. PMID 23284632.
• "Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines. ". Chin J Cancer. 2012. PMID 23114090.
• "Malic enzyme gene polymorphism is associated with responsiveness in circulating parathyroid hormone after long-term calcium supplementation.". J Nutr Health Aging. 2012. PMID 22456781.