MEF2A

Protein sy'n cael ei godio yn y corff dynol gan y genyn MEF2A yw MEF2A a elwir hefyd yn Myocyte-specific enhancer factor 2A a Myocyte enhancer factor 2a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.3.

MEF2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1C7U, 1EGW, 1LEW, 3KOV, 3MU6, 3P57
Dynodwyr
Cyfenwau	MEF2A, ADCAD1, RSRFC4, RSRFC9, mef2, myocyte enhancer factor 2A
Dynodwyr allanol	OMIM: 600660 HomoloGene: 4080 GeneCards: MEF2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • GO:0001105 transcription coactivator activity • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • SMAD binding • protein kinase binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • transcription regulator complex • nucleoplasm • cnewyllyn cell • cytosol Prosesau biolegol • cellular response to calcium ion • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • mitochondrial genome maintenance • dendrite morphogenesis • positive regulation of muscle cell differentiation • muscle organ development • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • ERK5 cascade • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • cardiac conduction • mitochondrion distribution • ventricular cardiac myofibril assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process • positive regulation of cardiac muscle hypertrophy • transcription by RNA polymerase II • MAPK cascade • positive regulation of glucose import Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4205	n/a
Ensembl	ENSG00000068305	n/a
UniProt	Q02078	n/a
RefSeq (mRNA)	NM_001130926 NM_001130927 NM_001130928 NM_001171894 NM_005587 NM_001319206 NM_001352614 NM_001352615 NM_001352616 NM_001352617 NM_001352618 NM_001365201 NM_001365202 NM_001365203 NM_001365204 NM_001365205 NM_001365206 NM_001365207 NM_001365208 NM_001365209 NM_001365210 NM_001365211 NM_001393558 NM_001393559 NM_001393560 NM_001393561	n/a
RefSeq (protein)	NP_001124398 NP_001124399 NP_001124400 NP_001165365 NP_001306135 NP_005578 NP_001339543 NP_001339544 NP_001339545 NP_001339546 NP_001339547 NP_001352130 NP_001352131 NP_001352132 NP_001352133 NP_001352134 NP_001352135 NP_001352136 NP_001352137 NP_001352138 NP_001352139 NP_001352140	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MEF2A.

• mef2
• ADCAD1
• RSRFC4
• RSRFC9

Llyfryddiaeth

• "Novel 6-bp deletion in MEF2A linked to premature coronary artery disease in a large Chinese family. ". Mol Med Rep. 2016. PMID 27221044.
• "Linkage and whole genome sequencing identify a locus on 6q25-26 for formal thought disorder and implicate MEF2A regulation. ". Schizophr Res. 2015. PMID 26421691.
• "Association of MEF2A gene 3'UTR mutations with coronary artery disease. ". Genet Mol Res. 2015. PMID 26400337.
• "MEF2A gene mutations and susceptibility to coronary artery disease in the Chinese population. ". Genet Mol Res. 2014. PMID 25366733.
• "MEF2 transcription factors promotes EMT and invasiveness of hepatocellular carcinoma through TGF-β1 autoregulation circuitry.". Tumour Biol. 2014. PMID 25087096.