MID1

Protein sy'n cael ei godio yn y corff dynol gan y genyn MID1 yw MID1 a elwir hefyd yn Midline 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp22.2.

MID1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DQ5, 2FFW, 2JUN, 5IM8
Dynodwyr
Cyfenwau	MID1, BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY, midline 1, GBBB
Dynodwyr allanol	OMIM: 300552 HomoloGene: 7837 GeneCards: MID1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • microtubule binding • zinc ion binding • metal ion binding • phosphoprotein binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding • transferase activity Cydrannau o'r gell • cytoplasm • cytosol • microtubule cytoskeleton • spindle • intracellular anatomical structure • microtubule associated complex • cytoplasmic microtubule • microtubule • Cytosgerbwd Prosesau biolegol • pattern specification process • interferon-gamma-mediated signaling pathway • negative regulation of microtubule depolymerization • protein localization to microtubule • microtubule cytoskeleton organization • positive regulation of stress-activated MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4281	n/a
Ensembl	ENSG00000101871	n/a
UniProt	O15344	n/a
RefSeq (mRNA)	NM_000381 NM_001098624 NM_001193277 NM_001193278 NM_001193279 NM_001193280 NM_001193281 NM_033289 NM_033290 NM_033291 NM_001347733	n/a
RefSeq (protein)	NP_000372 NP_001092094 NP_001180206 NP_001180207 NP_001180208 NP_001180209 NP_001334662 NP_150631 NP_150632	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MID1.

• OS
• FXY
• OSX
• OGS1
• XPRF
• BBBG1
• GBBB1
• MIDIN
• RNF59
• ZNFXY
• TRIM18

Llyfryddiaeth

• "Structural and functional observations of the P151L MID1 mutation reveal alpha4 plays a significant role in X-linked Opitz Syndrome. ". FEBS J. 2017. PMID 28548391.
• "Ossification of the posterior ligament is mediated by osterix via inhibition of the β-catenin signaling pathway. ". Exp Cell Res. 2016. PMID 27693496.
• "Solution structure of the microtubule-targeting COS domain of MID1. ". FEBS J. 2016. PMID 27367845.
• "Molecular dynamics simulation reveals insights into the mechanism of unfolding by the A130T/V mutations within the MID1 zinc-binding Bbox1 domain. ". PLoS One. 2015. PMID 25874572.
• "R368X mutation in MID1 among recurrent mutations in patients with X-linked Opitz G/BBB syndrome.". Clin Dysmorphol. 2015. PMID 25304119.