MKNK2

Protein sy'n cael ei godio yn y corff dynol gan y genyn MKNK2 yw MKNK2 a elwir hefyd yn MAP kinase-interacting serine/threonine-protein kinase 2 a MAP kinase interacting serine/threonine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

MKNK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AC3, 2AC5
Dynodwyr
Cyfenwau	MKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
Dynodwyr allanol	OMIM: 605069 HomoloGene: 49674 GeneCards: MKNK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • calcium-dependent protein serine/threonine kinase activity • metal ion binding • calmodulin binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • calmodulin-dependent protein kinase activity • ATP binding Cydrannau o'r gell • cytoplasm • PML body • nuclear body • cnewyllyn cell • nucleoplasm Prosesau biolegol • GO:0007243 intracellular signal transduction • phosphorylation • protein phosphorylation • cell surface receptor signaling pathway • cellular response to arsenic-containing substance • GO:0035404 peptidyl-serine phosphorylation • extrinsic apoptotic signaling pathway in absence of ligand • protein autophosphorylation • regulation of translation • GO:0097285 apoptotic process • hemopoiesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2872	n/a
Ensembl	ENSG00000099875	n/a
UniProt	Q9HBH9	n/a
RefSeq (mRNA)	NM_199054 NM_017572	n/a
RefSeq (protein)	NP_060042 NP_951009	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MKNK2.

• MNK2
• GPRK7

Llyfryddiaeth

• "The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). ". Front Biosci. 2008. PMID 18508592.
• "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site. ". Structure. 2005. PMID 16216586.
• "Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells. ". Oncotarget. 2014. PMID 25193863.
• "Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. ". Oncogene. 2013. PMID 22797067.
• "Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.". J Biol Chem. 2008. PMID 18299328.