MMP8

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP8 yw MMP8 a elwir hefyd yn Matrix metallopeptidase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.2.

MMP8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A86, 1JAP, 1I76, 1ZVX, 3TT4, 2OY2, 1ZS0, 1JAN, 1MMB, 1I73, 1A85, 1KBC, 1ZP5, 1JH1, 3DPF, 1JAQ, 3DPE, 1BZS, 4QKZ, 1JAO, 3DNG, 2OY4, 1MNC
Dynodwyr
Cyfenwau	MMP8, CLG1, HNC, MMP-8, PMNL-CL, matrix metallopeptidase 8
Dynodwyr allanol	OMIM: 120355 HomoloGene: 22482 GeneCards: MMP8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • GO:0070122 peptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • serine-type endopeptidase activity • metalloendopeptidase activity • endopeptidase activity Cydrannau o'r gell • GO:0005578 extracellular matrix • extracellular region • specific granule lumen • tertiary granule lumen • extracellular space • collagen-containing extracellular matrix Prosesau biolegol • collagen catabolic process • extracellular matrix disassembly • endodermal cell differentiation • proteolysis • neutrophil degranulation • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • negative regulation of interleukin-10 production • positive regulation of interleukin-6 production • positive regulation of DNA binding • positive regulation of MAPK cascade • positive regulation of nitric oxide biosynthetic process • positive regulation of JNK cascade • regulation of neuroinflammatory response • positive regulation of neuroinflammatory response • positive regulation of NIK/NF-kappaB signaling • positive regulation of reactive oxygen species biosynthetic process • regulation of microglial cell activation • positive regulation of microglial cell activation • extracellular matrix organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4317	n/a
Ensembl	ENSG00000118113	n/a
UniProt	P22894	n/a
RefSeq (mRNA)	NM_001304441 NM_001304442 NM_002424	n/a
RefSeq (protein)	NP_001291370 NP_001291371 NP_002415	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP8.

• HNC
• CLG1
• MMP-8
• PMNL-CL

Llyfryddiaeth

• "The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. ". Br J Cancer. 2017. PMID 28772283.
• "MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population. ". Oncotarget. 2017. PMID 28423488.
• "Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function. ". Breast Cancer Res. 2017. PMID 28330493.
• "MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. ". Mediators Inflamm. 2016. PMID 27843200.
• "Association between genetic polymorphisms of MMP8 and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China.". Medicine (Baltimore). 2016. PMID 27631232.