NAE1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NAE1 yw NAE1 a elwir hefyd yn NEDD8 activating enzyme E1 subunit 1 a NEDD8-activating enzyme E1 regulatory subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q22.1.

NAE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1R4M, 1R4N, 1TT5, 1YOV, 2NVU, 3DBH, 3DBL, 3DBR, 3GZN
Dynodwyr
Cyfenwau	NAE1, A-116A10.1, APPBP1, ula-1, HPP1, NEDD8 activating enzyme E1 subunit 1
Dynodwyr allanol	OMIM: 603385 HomoloGene: 68370 GeneCards: NAE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • NEDD8 activating enzyme activity • GO:0001948, GO:0016582 protein binding • ubiquitin-like modifier activating enzyme activity • ubiquitin protein ligase binding • protein heterodimerization activity Cydrannau o'r gell • cytoplasm • Cellbilen • bilen • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • neuron apoptotic process • cell cycle • protein neddylation • regulation of neuron apoptotic process • mitotic DNA replication checkpoint signaling • GO:0072468 signal transduction • GO:0097285 apoptotic process • post-translational protein modification • protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8883	n/a
Ensembl	ENSG00000159593	n/a
UniProt	Q13564	n/a
RefSeq (mRNA)	NM_001018159 NM_001018160 NM_001286500 NM_003905	n/a
RefSeq (protein)	NP_001018169 NP_001018170 NP_001273429 NP_003896	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NAE1.

• HPP1
• ula-1
• APPBP1
• A-116A10.1

Llyfryddiaeth

• "Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. ". PLoS One. 2010. PMID 21151996.
• "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. ". Mol Cell. 2003. PMID 14690597.
• "A metal-based inhibitor of NEDD8-activating enzyme. ". PLoS One. 2012. PMID 23185368.
• "Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. ". Neuroreport. 2012. PMID 22182960.
• "Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma.". Int J Cancer. 2010. PMID 19795456.