NCK1

NCK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CI8, 2CI9, 2JS0, 2JS2, 2JW4
Dynodwyr
Cyfenwau	NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1
Dynodwyr allanol	OMIM: 600508 HomoloGene: 38148 GeneCards: NCK1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein-macromolecule adaptor activity; • protein domain specific binding; • receptor tyrosine kinase binding; • protein kinase inhibitor activity; • GO:0001948, GO:0016582 protein binding; • cytoskeletal anchor activity; • signaling receptor complex adaptor activity; • signaling receptor binding; • eukaryotic initiation factor eIF2 binding; • ephrin receptor binding; • cadherin binding; • GO:0032947 molecular adaptor activity;
Cydrannau o'r gell	• cytosol; • ribosom; • cell-cell junction; • vesicle membrane; • protein phosphatase type 1 complex; • Reticwlwm endoplasmig; • cnewyllyn cell; • cytoplasm; • Cellbilen;
Prosesau biolegol	• positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • Fc-gamma receptor signaling pathway involved in phagocytosis; • actin filament organization; • positive regulation of translation in response to endoplasmic reticulum stress; • substrate-dependent cell migration, cell extension; • signal complex assembly; • negative regulation of cell death; • positive regulation of cap-independent translational initiation; • positive regulation of cap-dependent translational initiation; • peptidyl-serine dephosphorylation; • vascular endothelial growth factor receptor signaling pathway; • response to other organism; • positive regulation of T cell proliferation; • negative regulation of peptidyl-serine phosphorylation; • negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; • T cell receptor signaling pathway; • negative regulation of PERK-mediated unfolded protein response; • cell migration; • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • regulation of translation; • T cell activation; • lamellipodium assembly; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of protein kinase activity; • positive regulation of actin filament polymerization; • regulation of cell migration; • ephrin receptor signaling pathway; • positive regulation of neuron projection development; • GO:1903105 negative regulation of insulin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	4690
	n/a
	ENSG00000158092
	n/a
	P16333
	n/a
	NM_006153; NM_001190796; NM_001291999
	n/a
	NP_001177725; NP_001278928; NP_006144
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCK1 yw NCK1 a elwir hefyd yn Cytoplasmic protein NCK1 a NCK adaptor protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCK1.

NCK
nck-1
NCKalpha

Llyfryddiaeth

"Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning. ". J Immunol. 2016. PMID 26590318.
"Actin remodeling by Nck regulates endothelial lumen formation. ". Mol Biol Cell. 2015. PMID 26157164.
"Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis. ". PLoS One. 2013. PMID 24086708.
"OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2. ". BMC Cancer. 2013. PMID 23706161.
"Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function.". Clin Exp Immunol. 2012. PMID 22132889.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NCK1 - Cronfa NCBI

[2]

[1]