NCL

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCL yw NCL a elwir hefyd yn Nucleolin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q37.1.

NCL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FC8, 2FC9, 2KRR
Dynodwyr
Cyfenwau	NCL, C23, nucleolin, Nsr1
Dynodwyr allanol	OMIM: 164035 HomoloGene: 136488 GeneCards: NCL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • telomeric DNA binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • RNA binding • identical protein binding • nucleic acid binding • DNA topoisomerase binding • mRNA 5'-UTR binding Cydrannau o'r gell • cytoplasm • bilen • nucleoplasm • cell cortex • nucleolus • cytoplasmic ribonucleoprotein granule • extracellular exosome • cnewyllyn cell • ribonucleoprotein complex Prosesau biolegol • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I • angiogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to epidermal growth factor stimulus • negative regulation of translation • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4691	n/a
Ensembl	ENSG00000115053	n/a
UniProt	P19338	n/a
RefSeq (mRNA)	NM_005381	n/a
RefSeq (protein)	NP_005372	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCL.

• C23
• Nsr1

Llyfryddiaeth

• "Nucleolin is a nuclear target of heparan sulfate derived from glypican-1. ". Exp Cell Res. 2017. PMID 28300561.
• "Engineered antibody CH2 domains binding to nucleolin: Isolation, characterization and improvement of aggregation. ". Biochem Biophys Res Commun. 2017. PMID 28202413.
• "Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients. ". PLoS One. 2017. PMID 28103300.
• "Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression. ". PLoS One. 2016. PMID 27711134.
• "Expression of Nucleolin Affects Microtubule Dynamics.". PLoS One. 2016. PMID 27309529.