NCOA2

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCOA2 yw NCOA2 a elwir hefyd yn Nuclear receptor coactivator 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q13.3.

NCOA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23, 2FAI, 2G44, 2G5O, 2P15, 2P1T, 2P1U, 2P1V, 2Q7J, 2Q7L, 2ZXZ, 2ZY0, 3A9E, 3DZU, 3DZY, 3E00, 3E7C, 3E94, 3FUG, 3GN8, 3K23, 3KWY, 3KYT, 3L0E, 3L0L, 3O1D, 3O1E, 3OAP, 3OZJ, 3PCU, 3PLZ, 3Q95, 3Q97, 3R5M, 3UP0, 3UP3, 4DOS, 4E2J, 4FHH, 4FHI, 4IA1, 4IA2, 4IA3, 4IA7, 4IQR, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 2LDC, 2YJD, 3CLD, 3ERD, 3K22, 4CSJ, 4K4J, 4K6I, 4M8E, 4M8H, 4NIE, 4NQA, 4OC7, 4P6W, 4P6X, 4POH, 4POJ, 4PP3, 4PP5, 4PP6, 4PPP, 4PPS, 4PXM, 4Q0A, 4WG0, 4QE6, 4QE8, 4RFW, 4RMC, 4RMD, 4RME, 4ZN9, 4ZO1, 4RUO, 5APJ, 4UDD, 4PLD, 4PLE, 4UDC, 5APH, 5DMC, 5DKB, 5DMF, 4ZNV, 5DVS, 5DL4, 5E0W, 5E19, 4ZUC, 5DI7, 5I4V, 5E0X, 5E1C, 4ZWK, 5DYD, 5DIG, 5DKG, 5DTV, 5EC9, 5DX3, 5DRM, 5BP6, 5DYB, 5DLR, 5E14, 5DXK, 5DUH, 5DVV, 5DU5, 5DXP, 5DP0, 4ZNS, 5DZ3, 5DXR, 5DXQ, 5DZI, 4ZNT, 4ZNW, 5DID, 5DXM, 5EHJ, 5BQ4, 5DY8, 4ZSH, 5DXB, 5DUG, 5DK9, 5EIT, 5BPR, 5DWJ, 5DWI, 5HYR, 5DKS, 4ZUB, 5EI1, 5DZ0, 4ZNU, 4ZNH, 5E15, 4ZN7, 5DZ1, 5DUE, 4ZWH, 5EGV, 5BNU, 5DIE, 5DKE, 5DWG, 5DZH, 5DRJ, 5DWE
Dynodwyr
Cyfenwau	NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2
Dynodwyr allanol	OMIM: 601993 HomoloGene: 4768 GeneCards: NCOA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein dimerization activity • GO:0001105 transcription coactivator activity • transcription factor binding • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • nuclear receptor coactivator activity • RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding • signaling receptor binding • nuclear receptor binding • aryl hydrocarbon receptor binding • protein domain specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell • nuclear body • GO:0009327 protein-containing complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • cellular response to Thyroglobulin triiodothyronine • proses rythmig • GO:1901227 negative regulation of transcription by RNA polymerase II • circadian regulation of gene expression • transcription, DNA-templated • cellular response to hormone stimulus • regulation of glucose metabolic process • Rhythm circadaidd • bile acid and bile salt transport • GO:0045996 negative regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • locomotor rhythm • intracellular receptor signaling pathway • regulation of lipid metabolic process • regulation of gene expression • response to progesterone Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10499	n/a
Ensembl	ENSG00000140396	n/a
UniProt	Q15596	n/a
RefSeq (mRNA)	NM_006540 NM_001321703 NM_001321707 NM_001321711 NM_001321712 NM_001321713	n/a
RefSeq (protein)	NP_001308632 NP_001308636 NP_001308640 NP_001308641 NP_001308642 NP_006531	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCOA2.

• SRC2
• TIF2
• GRIP1
• KAT13C
• NCoA-2
• bHLHe75

Llyfryddiaeth

• "Production of unstable proteins through the formation of stable core complexes. ". Nat Commun. 2016. PMID 26983699.
• "Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling. ". Biochem Biophys Res Commun. 2016. PMID 26970301.
• "3, 3', 5-triiodo-L-thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells From Human Umbilical Cord Stroma Through SRC2. ". J Cell Biochem. 2016. PMID 26869487.
• "NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer. ". Genes Chromosomes Cancer. 2016. PMID 26799514.
• "ETV3-NCOA2 in indeterminate cell histiocytosis: clonal translocation supports sui generis.". Blood. 2015. PMID 26438513.