NCOR2

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCOR2 yw NCOR2 a elwir hefyd yn Nuclear receptor corepressor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.31.

NCOR2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2RT5, 4OAR, 2L5G, 2LTP, 1KKQ, 3R2A, 2ODD, 4A69, 3R29, 1XC5, 1R2B,%%s1KKQ, 1R2B, 1XC5, 2GPV, 2LTP, 3R29, 3R2A, 4A69, 2L5G, 2ODD, 2RT5, 4OAR
Dynodwyr
Cyfenwau	NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
Dynodwyr allanol	OMIM: 600848 HomoloGene: 31370 GeneCards: NCOR2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • protein N-terminus binding • histone deacetylase binding • Notch binding • DNA binding • transcription factor binding • nuclear receptor binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding • sequence-specific DNA binding • glucocorticoid receptor binding • retinoic acid receptor binding • GO:0032403 protein-containing complex binding • retinoid X receptor binding Cydrannau o'r gell • transcription repressor complex • nuclear body • bilen • histone deacetylase complex • nuclear matrix • nucleoplasm • cnewyllyn cell • chromatin Prosesau biolegol • negative regulation of production of miRNAs involved in gene silencing by miRNA • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of lipid metabolic process • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of androgen receptor signaling pathway • lactation • response to organonitrogen compound • response to estradiol • estrous cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9612	n/a
Ensembl	ENSG00000196498	n/a
UniProt	Q9Y618	n/a
RefSeq (mRNA)	NM_006312 NM_001077261 NM_001206654	n/a
RefSeq (protein)	NP_001070729 NP_001193583 NP_006303 NP_001193583.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCOR2.

• SMRT
• TRAC
• CTG26
• SMRTE
• TRAC1
• N-CoR2
• TNRC14
• TRAC-1
• SMAP270
• SMRTE-tau

Llyfryddiaeth

• "Association of Forced Vital Capacity with the Developmental Gene NCOR2. ". PLoS One. 2016. PMID 26836265.
• "Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex. ". J Biol Chem. 2015. PMID 26055705.
• "SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity. ". Cancer Res. 2013. PMID 23117886.
• "Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence. ". Breast Cancer Res Treat. 2012. PMID 23015261.
• "Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression.". Biochem Biophys Res Commun. 2012. PMID 22695118.