NEIL1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEIL1 yw NEIL1 a elwir hefyd yn Endonuclease 8-like 1 a Nei like DNA glycosylase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q24.2.

NEIL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TDH, 4NRV, 5ITY, 5ITQ, 5ITU, 5ITX, 5ITR, 5ITT
Dynodwyr
Cyfenwau	NEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1
Dynodwyr allanol	OMIM: 608844 HomoloGene: 11616 GeneCards: NEIL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • zinc ion binding • hydrolase activity, hydrolyzing N-glycosyl compounds • hydrolase activity, acting on glycosyl bonds • damaged DNA binding • protein C-terminus binding • catalytic activity • lyase activity • nucleic acid binding • hydrolase activity • DNA N-glycosylase activity • DNA-(apurinic or apyrimidinic site) endonuclease activity • class I DNA-(apurinic or apyrimidinic site) endonuclease activity Cydrannau o'r gell • cytoplasm • Cromosom • microtubule organizing center • Cytosgerbwd • cnewyllyn cell • nucleoplasm Prosesau biolegol • nucleotide-excision repair • GO:0001306 response to oxidative stress • cellular response to DNA damage stimulus • depyrimidination • negative regulation of nuclease activity • metabolaeth • GO:0100026 DNA repair • base-excision repair Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	79661	n/a
Ensembl	ENSG00000140398	n/a
UniProt	Q96FI4	n/a
RefSeq (mRNA)	NM_001256552 NM_024608 NM_001352519 NM_001352520	n/a
RefSeq (protein)	NP_001243481 NP_078884 NP_001339448 NP_001339449	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEIL1.

• FPG1
• NEI1
• hFPG1

Llyfryddiaeth

• "NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations. ". Gene. 2015. PMID 26095805.
• "Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. ". DNA Repair (Amst). 2014. PMID 24382305.
• "NEIL1 is a candidate gene associated with common variable immunodeficiency in a patient with a chromosome 15q24 deletion. ". Clin Immunol. 2017. PMID 28093361.
• "Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response. ". Nucleic Acids Res. 2017. PMID 27924031.
• "The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.". J Biol Chem. 2015. PMID 26134572.