NLRP1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NLRP1 yw NLRP1 a elwir hefyd yn NLR family pyrin domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.2.

NLRP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PN5, 3KAT, 4IFP, 4IM6
Dynodwyr
Cyfenwau	NLRP1, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1, NLR family, pyrin domain containing 1, NLR family pyrin domain containing 1, MSPC, AIADK, JRRP
Dynodwyr allanol	OMIM: 606636 HomoloGene: 19080 GeneCards: NLRP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • nucleotide binding • cysteine-type endopeptidase activator activity involved in apoptotic process • ATP binding • enzyme binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • inflammasome complex • cnewyllyn cell • intracellular anatomical structure • nucleoplasm • cytosol • NLRP1 inflammasome complex Prosesau biolegol • neuron apoptotic process • regulation of apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to muramyl dipeptide • GO:0097285 apoptotic process • defense response to bacterium • regulation of inflammatory response • immune system process • inflammatory response • innate immune response • GO:0022415 viral process • NLRP1 inflammasome complex assembly • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	22861	n/a
Ensembl	ENSG00000091592	n/a
UniProt	Q9C000	n/a
RefSeq (mRNA)	NM_033007 NM_001033053 NM_014922 NM_033004 NM_033006	n/a
RefSeq (protein)	NP_001028225 NP_055737 NP_127497 NP_127499 NP_127500	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NLRP1.

• NAC
• MSPC
• AIADK
• CARD7
• CIDED
• NALP1
• SLEV1
• DEFCAP
• PP1044
• VAMAS1
• CLR17.1
• DEFCAP-L/S

Llyfryddiaeth

• "Aspirin therapy inhibits NLRP1 (nucleotide-binding domain-like receptor protein 1) inflammasome gene expression in patients with peripheral artery disease. ". J Vasc Surg. 2015. PMID 25814374.
• "NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model. ". J Neuroinflammation. 2015. PMID 25626361.
• "NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma. ". Oncogene. 2017. PMID 28263976.
• "Effect of Simvastatin Treatment on "In Vitro" NLRP1 Inflammasome Expression in Peripheral Arterial Disease. ". Ann Vasc Surg. 2016. PMID 27423725.
• "Nlrp1 inflammasome is downregulated in trauma patients.". J Mol Med (Berl). 2015. PMID 26232934.