NOS3

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOS3 yw NOS3 a elwir hefyd yn Nitric oxide synthase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q36.1.

NOS3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P
Dynodwyr
Cyfenwau	NOS3, ECNOS, eNOS, nitric oxide synthase 3
Dynodwyr allanol	OMIM: 163729 HomoloGene: 504 GeneCards: NOS3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • FMN binding • actin monomer binding • flavin adenine dinucleotide binding • scaffold protein binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • GO:0001948, GO:0016582 protein binding • heme binding • NADP binding • oxidoreductase activity • cadmium ion binding • nitric-oxide synthase activity • NADPH-hemoprotein reductase activity Cydrannau o'r gell • cytoplasm • endocytic vesicle membrane • cytosol • Golgi apparatus • bilen • Golgi membrane • Cellbilen • caveola • Cytosgerbwd • cnewyllyn cell • vesicle membrane Prosesau biolegol • negative regulation of muscle hyperplasia • ovulation from ovarian follicle • positive regulation of guanylate cyclase activity • nitric oxide biosynthetic process • regulation of systemic arterial blood pressure by endothelin • regulation of sodium ion transport • lung development • negative regulation of blood pressure • removal of superoxide radicals • regulation of nitric-oxide synthase activity • mitochondrion organization • response to heat • in utero embryonic development • negative regulation of hydrolase activity • cell redox homeostasis • arginine catabolic process • response to fluid shear stress • regulation of blood pressure • negative regulation of platelet activation • blood vessel remodeling • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • angiogenesis • negative regulation of potassium ion transport • nitric oxide mediated signal transduction • negative regulation of calcium ion transport • smooth muscle hyperplasia • regulation of the force of heart contraction by chemical signal • endothelial cell migration • lipopolysaccharide-mediated signaling pathway • negative regulation of cell population proliferation • vasodilation • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion morphogenesis • GO:1901313 positive regulation of gene expression • homeostasis of number of cells within a tissue • ventricular septum morphogenesis • negative regulation of biomineral tissue development • response to hormone • response to lipopolysaccharide • regulation of nervous system process • positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4846	n/a
Ensembl	ENSG00000164867	n/a
UniProt	P29474	n/a
RefSeq (mRNA)	NM_000603 NM_001160109 NM_001160110 NM_001160111	n/a
RefSeq (protein)	NP_000594 NP_001153581 NP_001153582 NP_001153583	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOS3.

• eNOS
• ECNOS

Llyfryddiaeth

• "Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study. ". BMC Med Genet. 2017. PMID 29132319.
• "The Relation Between Endothelial Nitric Oxide Synthase Polymorphisms and Normal Tension Glaucoma. ". J Glaucoma. 2017. PMID 28777225.
• "Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis. ". Genet Mol Res. 2017. PMID 28481400.
• "Association of Endothelial Nitric Oxide Synthase Gene Polymorphism with Susceptibility and Nephritis Development of Henoch-Schönlein Purpura in Chinese Han Children. ". Genet Test Mol Biomarkers. 2017. PMID 28409662.
• "Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study.". Bull Exp Biol Med. 2017. PMID 28361419.