NOTCH1

NOTCH1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA
Dynodwyr
Cyfenwau	NOTCH1, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1, notch receptor 1
Dynodwyr allanol	OMIM: 190198 HomoloGene: 32049 GeneCards: NOTCH1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • Notch binding; • GO:0048551 enzyme inhibitor activity; • metal ion binding; • enzyme binding; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • sequence-specific DNA binding; • protein heterodimerization activity; • chromatin DNA binding; • transmembrane signaling receptor activity; • signaling receptor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • adherens junction; • extracellular region; • cnewyllyn cell; • cell surface; • apical plasma membrane; • Reticwlwm endoplasmig; • integral component of membrane; • Golgi apparatus; • receptor complex; • Cellbilen; • nucleoplasm; • MAML1-RBP-Jkappa- ICN1 complex; • cyrion cell; • endoplasmic reticulum membrane; • Golgi membrane; • acrosomal vesicle; • GO:0016023 cytoplasmic vesicle;
Prosesau biolegol	• cardiac vascular smooth muscle cell development; • endoderm development; • pulmonary valve morphogenesis; • positive regulation of endothelial cell differentiation; • regulation of somitogenesis; • cell differentiation in spinal cord; • negative regulation of neuron differentiation; • regulation of extracellular matrix assembly; • distal tubule development; • negative regulation of glial cell proliferation; • epithelial to mesenchymal transition involved in endocardial cushion formation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • aortic valve morphogenesis; • oligodendrocyte differentiation; • endocardium morphogenesis; • negative regulation of osteoblast differentiation; • negative regulation of stem cell differentiation; • negative regulation of ossification; • heart looping; • negative regulation of photoreceptor cell differentiation; • arterial endothelial cell differentiation; • atrioventricular valve morphogenesis; • Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; • humoral immune response; • foregut morphogenesis; • negative regulation of oligodendrocyte differentiation; • positive regulation of cardiac muscle cell proliferation; • GO:0090343, GO:0090342 regulation of developmental process; • mesenchymal cell development; • animal organ regeneration; • angiogenesis; • spermatogenesis; • negative regulation of pro-B cell differentiation; • regulation of cardioblast proliferation; • hair follicle morphogenesis; • vasculogenesis involved in coronary vascular morphogenesis; • negative regulation of canonical Wnt signaling pathway; • regulation of neurogenesis; • negative regulation of cell population proliferation; • collecting duct development; • positive regulation of neuroblast proliferation; • cilium assembly; • heart trabecula morphogenesis; • atrioventricular node development; • negative regulation of myoblast differentiation; • cell fate commitment; • GO:0009373 regulation of transcription, DNA-templated; • cellular response to follicle-stimulating hormone stimulus; • lung development; • negative regulation of inner ear auditory receptor cell differentiation; • cardiac septum morphogenesis; • ventricular septum morphogenesis; • negative regulation of cell differentiation; • coronary artery morphogenesis; • response to muramyl dipeptide; • cardiac left ventricle morphogenesis; • in utero embryonic development; • negative regulation of cell death; • endocardial cell differentiation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • prostate gland epithelium morphogenesis; • embryonic limb morphogenesis; • growth involved in heart morphogenesis; • neural tube development; • pericardium morphogenesis; • epidermis development; • cardiac atrium morphogenesis; • transcription initiation from RNA polymerase II promoter; • cardiac right atrium morphogenesis; • negative regulation of cell-substrate adhesion; • cell migration involved in endocardial cushion formation; • cell differentiation; • venous endothelial cell differentiation; • regulation of inner ear auditory receptor cell differentiation; • GO:0048553 negative regulation of catalytic activity; • inflammatory response to antigenic stimulus; • positive regulation of astrocyte differentiation; • positive regulation of epithelial cell proliferation; • cardiac right ventricle formation; • endocardial cushion development; • cell fate specification; • positive regulation of keratinocyte differentiation; • positive regulation of glial cell differentiation; • negative regulation of neurogenesis; • glomerular mesangial cell development; • sprouting angiogenesis; • glial cell differentiation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • cardiac muscle cell proliferation; • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; • positive regulation of epithelial to mesenchymal transition; • ventricular trabecula myocardium morphogenesis; • neuronal stem cell population maintenance; • negative regulation of cell migration involved in sprouting angiogenesis; • response to lipopolysaccharide; • compartment pattern specification; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • neuron differentiation; • epithelial to mesenchymal transition; • positive regulation of BMP signaling pathway; • skeletal muscle cell differentiation; • regulation of gene expression; • positive regulation of viral genome replication; • regulation of epithelial cell proliferation involved in prostate gland development; • GO:0045996 negative regulation of transcription, DNA-templated; • cardiac ventricle morphogenesis; • branching morphogenesis of an epithelial tube; • positive regulation of receptor signaling pathway via JAK-STAT; • negative regulation of anoikis; • Notch signaling involved in heart development; • coronary vein morphogenesis; • apoptotic process involved in embryonic digit morphogenesis; • regulation of cell migration; • axonogenesis; • tissue regeneration; • positive regulation of cell migration; • somatic stem cell division; • cardiac muscle tissue morphogenesis; • negative regulation of endothelial cell chemotaxis; • keratinocyte differentiation; • negative regulation of BMP signaling pathway; • endocardial cushion morphogenesis; • endocardium development; • multicellular organism development; • auditory receptor cell fate commitment; • response to corticosteroid; • tube formation; • determination of left/right symmetry; • astrocyte differentiation; • negative regulation of calcium ion-dependent exocytosis; • brain development; • regulation of cell population proliferation; • positive regulation of cell population proliferation; • negative regulation of myotube differentiation; • positive regulation of apoptotic process; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • mitral valve formation; • liver development; • cardiac chamber formation; • forebrain development; • cellular response to vascular endothelial growth factor stimulus; • neuron fate commitment; • regulation of epithelial cell proliferation; • regulation of Notch signaling pathway; • left/right axis specification; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cardiac epithelial to mesenchymal transition; • embryonic hindlimb morphogenesis; • positive regulation of aorta morphogenesis; • venous blood vessel morphogenesis; • Notch signaling pathway; • negative regulation of gene expression; • negative regulation of growth rate; • positive regulation of Ras protein signal transduction; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of transcription of Notch receptor target; • positive regulation of Notch signaling pathway; • outflow tract morphogenesis; • coronary sinus valve morphogenesis; • negative regulation of cell proliferation involved in heart valve morphogenesis; • negative regulation of extracellular matrix constituent secretion; • negative regulation of cardiac muscle hypertrophy; • GO:1901313 positive regulation of gene expression; • homeostasis of number of cells within a tissue; • negative regulation of biomineral tissue development; • positive regulation of apoptotic process involved in morphogenesis; • positive regulation of cardiac epithelial to mesenchymal transition; • negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologau
	4851
	n/a
	ENSG00000148400
	n/a
	P46531
	n/a
	NM_017617
	n/a
	NP_060087
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOTCH1 yw NOTCH1 a elwir hefyd yn Notch 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q34.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOTCH1.

hN1
AOS5
TAN1
AOVD1

Llyfryddiaeth

"Correlation between histone acetylation and expression of Notch1 in human lung carcinoma and its possible role in combined small-cell lung carcinoma. ". Lab Invest. 2017. PMID 28414324.
"Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure. ". J Biol Chem. 2017. PMID 28302721.
"Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. ". Am J Surg Pathol. 2017. PMID 28914715.
"Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia. ". BMC Ophthalmol. 2017. PMID 28764685.
"Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects.". Pediatr Cardiol. 2017. PMID 28608148.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NOTCH1 - Cronfa NCBI

[2]

[1]