NPLOC4

Protein sy'n cael ei godio yn y corff dynol gan y genyn NPLOC4 yw NPLOC4 a elwir hefyd yn Nuclear protein localization 4 homolog (S. cerevisiae), isoform CRA_a a Nuclear protein localization protein 4 homolog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

NPLOC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2PJH
Dynodwyr
Cyfenwau	NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
Dynodwyr allanol	OMIM: 606590 HomoloGene: 5403 GeneCards: NPLOC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ubiquitin binding • GO:0001948, GO:0016582 protein binding • metal ion binding • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear outer membrane-endoplasmic reticulum membrane network • Reticwlwm endoplasmig • cnewyllyn cell • UFD1-NPL4 complex • nucleoplasm • VCP-NPL4-UFD1 AAA ATPase complex Prosesau biolegol • error-free translesion synthesis • retrograde protein transport, ER to cytosol • Golgi organization • ubiquitin-dependent ERAD pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of type I interferon production • negative regulation of RIG-I signaling pathway • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55666	n/a
Ensembl	ENSG00000182446	n/a
UniProt	Q8TAT6	n/a
RefSeq (mRNA)	NM_017921 NM_001369698	n/a
RefSeq (protein)	NP_060391 NP_001356627 NP_060391.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NPLOC4.

• NPL4

Llyfryddiaeth

• "Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. ". J Biol Chem. 2003. PMID 12644454.
• "A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization. ". Int J Biochem Cell Biol. 2013. PMID 23333620.
• "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation. ". Biochem Biophys Res Commun. 2007. PMID 17331469.
• "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD. ". Exp Cell Res. 2008. PMID 18586029.
• "The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism.". J Biol Chem. 2004. PMID 15371428.