Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1I2 yw NR1I2 a elwir hefyd yn Nuclear receptor subfamily 1 group I member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q13.33.[2]
NR1I2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Protein_NR1I2_PDB_1ilg.png/250px-Protein_NR1I2_PDB_1ilg.png) |
Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Rhestr o ddynodwyr PDB |
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1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G, 4XAO, 5A86 |
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Dynodwyr |
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Cyfenwau | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR, nuclear receptor subfamily 1 group I member 2 |
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Dynodwyr allanol | OMIM: 603065 HomoloGene: 40757 GeneCards: NR1I2 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity
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Cydrannau o'r gell | • cnewyllyn cell • nucleoplasm • nuclear body • intermediate filament cytoskeleton • RNA polymerase II transcription regulator complex
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Prosesau biolegol | • steroid metabolic process • GO:0009373 regulation of transcription, DNA-templated • xenobiotic transport • xenobiotic export • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:1901313 positive regulation of gene expression • xenobiotic metabolic process • transcription initiation from RNA polymerase II promoter • GO:0045996 negative regulation of transcription, DNA-templated • GO:0072468 signal transduction • steroid hormone mediated signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway • multicellular organism development • cell differentiation
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1I2.
- BXR
- PAR
- PRR
- PXR
- SAR
- SXR
- ONR1
- PAR1
- PAR2
- PARq
- "TR47, a PAR1-based peptide, inhibits melanoma cell migration in vitro and metastasis in vivo. ". Biochem Biophys Res Commun. 2018. PMID 29196264.
- "Association of NR1I2 gene polymorphisms and time of progression to AIDS. ". Mem Inst Oswaldo Cruz. 2017. PMID 28327790.
- "Influence of a critical single nucleotide polymorphism on nuclear receptor PXR-promoter function. ". Cell Biol Int. 2017. PMID 28198586.
- "Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery. ". BMC Med Genet. 2016. PMID 27876007.
- "66034T/C polymorphism of the human pregnane X receptor (hPXR) as potential risk factor for drug resistance in epilepsy - Preliminary study.". Neurol Neurochir Pol. 2017. PMID 27836114.