NR3C1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR3C1 yw NR3C1 a elwir hefyd yn Glucocorticoid receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.3.

NR3C1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M2Z, 1NHZ, 1P93, 3BQD, 3CLD, 3E7C, 3H52, 3K22, 3K23, 4CSJ, 4HN5, 4HN6, 4LSJ, 4MDD, 4P6W, 4P6X, 5CBY, 5CBX, 4UDC, 4UDD, 5CBZ, 5CC1, 5EMQ, 5EMC, 5EMP
Dynodwyr
Cyfenwau	NR3C1, GCCR, GCR, GCRST, GR, GRL, nuclear receptor subfamily 3 group C member 1, Glucocorticoid Receptor
Dynodwyr allanol	OMIM: 138040 HomoloGene: 30960 GeneCards: NR3C1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • steroid hormone binding • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • glucocorticoid receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • steroid binding • GO:0001948, GO:0016582 protein binding • lipid binding • RNA binding • SUMO binding • Hsp90 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein kinase binding Cydrannau o'r gell • cytoplasm • nucleoplasm • mitochondrial matrix • mitocondria • cnewyllyn cell • Cytosgerbwd • spindle • microtubule organizing center • cytosol • nuclear speck • GO:0009327 protein-containing complex Prosesau biolegol • cellular response to steroid hormone stimulus • GO:0009373 regulation of transcription, DNA-templated • glucocorticoid mediated signaling pathway • transcription by RNA polymerase II • transcription initiation from RNA polymerase II promoter • glucocorticoid receptor signaling pathway • GO:0072468 signal transduction • steroid hormone mediated signaling pathway • cell cycle • Cellraniad • GO:0097285 apoptotic process • chromosome segregation • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • cellular response to dexamethasone stimulus • cellular response to transforming growth factor beta stimulus • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to glucocorticoid stimulus • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of pri-miRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2908	n/a
Ensembl	ENSG00000113580	n/a
UniProt	P04150 Q3MSN4	n/a
RefSeq (mRNA)	NM_000176 NM_001018074 NM_001018075 NM_001018076 NM_001018077 NM_001020825 NM_001024094 NM_001204258 NM_001204259 NM_001204260 NM_001204261 NM_001204262 NM_001204263 NM_001204264 NM_001204265 NM_001364180 NM_001364181 NM_001364182 NM_001364183 NM_001364184 NM_001364185	n/a
RefSeq (protein)	NP_000167 NP_001018084 NP_001018085 NP_001018086 NP_001018087 NP_001018661 NP_001019265 NP_001191187 NP_001191188 NP_001191189 NP_001191190 NP_001191191 NP_001191192 NP_001191193 NP_001191194 NP_001351109 NP_001351110 NP_001351111 NP_001351112 NP_001351113 NP_001351114 NP_000167.1 NP_001018084.1 NP_001018085.1 NP_001018086.1 NP_001018087.1 NP_001018661.1 NP_001019265.1 NP_001191187.1 NP_001191188.1 NP_001191189.1 NP_001191190.1 NP_001191191.1 NP_001191192.1 NP_001191193.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR3C1.

• GR
• GCR
• GRL
• GCCR
• GCRST

Llyfryddiaeth

• "Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor. ". Lab Invest. 2017. PMID 28759007.
• "Glucocorticoid receptor polymorphism in obesity and glucose homeostasis. ". Adv Clin Exp Med. 2017. PMID 28397446.
• "Glucocorticoid receptor variants in childhood attention-deficit/hyperactivity disorder and comorbid psychiatric disorders. ". Psychiatry Res. 2016. PMID 27741480.
• "Glomerular Glucocorticoid Receptors Expression and Clinicopathological Types of Childhood Nephrotic Syndrome. ". Fetal Pediatr Pathol. 2017. PMID 27690709.
• "Medical morbidities and DNA methylation of NR3C1 in preterm infants.". Pediatr Res. 2017. PMID 27653086.