NR3C2

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR3C2 yw NR3C2 a elwir hefyd yn Nuclear receptor subfamily 3 group C member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q31.23.

NR3C2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV, 3WFF, 3WFG, 4PF3, 4TNT, 4UDB, 4UDA, 5HCV
Dynodwyr
Cyfenwau	NR3C2, MCR, MLR, MR, NR3C2VIT, nuclear receptor subfamily 3 group C member 2
Dynodwyr allanol	OMIM: 600983 HomoloGene: 121495 GeneCards: NR3C2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • steroid binding • GO:0001948, GO:0016582 protein binding • lipid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • endoplasmic reticulum membrane • bilen • receptor complex • Reticwlwm endoplasmig • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • GO:0072468 signal transduction • steroid hormone mediated signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4306	n/a
Ensembl	ENSG00000151623	n/a
UniProt	P08235	n/a
RefSeq (mRNA)	NM_000901 NM_001166104 NM_001354819	n/a
RefSeq (protein)	NP_000892 NP_001159576 NP_001341748	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR3C2.

• MR
• MCR
• MLR
• NR3C2VIT

Llyfryddiaeth

• "Association of a Haplotype in the NR3C2 Gene, Encoding the Mineralocorticoid Receptor, With Chronic Central Serous Chorioretinopathy. ". JAMA Ophthalmol. 2017. PMID 28334414.
• "Mineralocorticoid receptor haplotype, estradiol, progesterone and emotional information processing. ". Psychoneuroendocrinology. 2017. PMID 27936434.
• "A novel frameshift mutation in NR3C2 leads to decreased expression of mineralocorticoid receptor: a family with renal pseudohypoaldosteronism type 1. ". Endocr J. 2017. PMID 27725360.
• "Mineralocorticoid Receptor (MR) trans-Activation of Inflammatory AP-1 Signaling: DEPENDENCE ON DNA SEQUENCE, MR CONFORMATION, AND AP-1 FAMILY MEMBER EXPRESSION. ". J Biol Chem. 2016. PMID 27650495.
• "Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth.". BMC Med Genet. 2015. PMID 26260058.