NRG1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NRG1 yw NRG1 a elwir hefyd yn Neuregulin 1 isoform HRG-beta2, Pro-neuregulin-1, membrane-bound isoform, Neuregulin 1 type IV fetal B beta 1a a Neuregulin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p12.

NRG1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HAE, 1HAF, 1HRE, 1HRF, 3U7U
Dynodwyr
Cyfenwau	NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, neuregulin 1
Dynodwyr allanol	OMIM: 142445 HomoloGene: 8509 GeneCards: NRG1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transmembrane receptor protein tyrosine kinase activator activity • protein tyrosine kinase activator activity • signaling receptor binding • cytokine activity • GO:0001104 transcription coregulator activity • growth factor activity • GO:0001948, GO:0016582 protein binding • chemorepellent activity • receptor tyrosine kinase binding • ErbB-2 class receptor binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ErbB-3 class receptor binding • integrin binding Cydrannau o'r gell • cytoplasm • bilen • synapse • extracellular region • cnewyllyn cell • apical plasma membrane • integral component of membrane • neuromuscular junction • Cellbilen • axon • cell body • integral component of plasma membrane • dendrite • axolemma • external side of plasma membrane • nucleoplasm • extracellular space • glutamatergic synapse • GABA-ergic synapse Prosesau biolegol • cardiac conduction system development • embryo development • positive regulation of Ras protein signal transduction • muscle organ development • oligodendrocyte differentiation • positive regulation of dendritic spine development • mammary gland development • axon ensheathment • cell communication • chemorepulsion involved in interneuron migration from the subpallium to the cortex • positive regulation of cardiac muscle cell proliferation • positive regulation of protein localization to cell surface • positive regulation of striated muscle cell differentiation • cell population proliferation • locomotory behavior • GO:1903363 negative regulation of protein catabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • cardiac muscle cell differentiation • endocardial cell differentiation • heart development • positive regulation of cell growth • cardiac muscle cell myoblast differentiation • positive regulation of peptidyl-tyrosine phosphorylation • synapse assembly • positive regulation of cardiac muscle cell differentiation • positive regulation of axon extension • peripheral nervous system development • startle response • regulation of protein heterodimerization activity • wound healing • glial cell differentiation • nervous system development • ventricular trabecula myocardium morphogenesis • glial cell fate commitment • negative regulation of cardiac muscle cell apoptotic process • GO:0045996 negative regulation of transcription, DNA-templated • regulation of protein homodimerization activity • neurotransmitter receptor metabolic process • positive regulation of protein kinase activity • negative regulation of neuron migration • neurogenesis • neural crest cell development • MAPK cascade • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of myelination • brain development • negative regulation of secretion • GO:0000767 cell morphogenesis • regulation of cell differentiation • ventricular cardiac muscle cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • neuron fate commitment • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • cell migration • positive regulation of cell adhesion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • phosphatidylinositol phosphate biosynthetic process • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • ERBB signaling pathway • activation of protein kinase B activity • regulation of cell motility • peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • ERBB2 signaling pathway • activation of transmembrane receptor protein tyrosine kinase activity • cardiac muscle tissue development • ERBB3 signaling pathway • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • ERBB4 signaling pathway • positive regulation of peptidyl-tyrosine autophosphorylation • myelination in peripheral nervous system • GO:0007243 intracellular signal transduction • postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3084	n/a
Ensembl	ENSG00000157168	n/a
UniProt	Q02297 Q7RTW3	n/a
RefSeq (mRNA)	NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964 NM_001322197 NM_001322201 NM_001322202 NM_001322205 NM_001322206 NM_001322207	n/a
RefSeq (protein)	NP_001153467 NP_001153468 NP_001153471 NP_001153473 NP_001153474 NP_001153476 NP_001153477 NP_001153479 NP_001153480 NP_001309126 NP_001309130 NP_001309131 NP_001309134 NP_001309135 NP_001309136 NP_004486 NP_039250 NP_039251 NP_039252 NP_039253 NP_039254 NP_039256 NP_039258 NP_039251.2 NP_001153471.1 NP_001309130.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NRG1.

• GGF
• HGL
• HRG
• NDF
• ARIA
• GGF2
• HRG1
• HRGA
• SMDF
• MST131
• MSTP131
• NRG1-IT2

Llyfryddiaeth

• "Meta-analysis reveals associations between genetic variation in the 5' and 3' regions of Neuregulin-1 and schizophrenia. ". Transl Psychiatry. 2017. PMID 28094814.
• "Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction. ". Eur J Pharmacol. 2017. PMID 27993643.
• "NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma. ". Cancer Med. 2016. PMID 27770508.
• "Neuregulin-1 (Nrg1) signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer's disease. ". Mol Med Rep. 2016. PMID 27486021.
• "A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study.". J Psychopharmacol. 2017. PMID 27353026.