NRP2

Protein sy'n cael ei godio yn y corff dynol gan y genyn NRP2 yw NRP2 a elwir hefyd yn Neuropilin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.3.

NRP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2
Dynodwyr
Cyfenwau	NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2
Dynodwyr allanol	OMIM: 602070 HomoloGene: 2875 GeneCards: NRP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • vascular endothelial growth factor-activated receptor activity • heparin binding • semaphorin receptor activity • growth factor binding • metal ion binding • GO:0019974 cytokine binding • GO:0001948, GO:0016582 protein binding • identical protein binding • signaling receptor activity Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • semaphorin receptor complex • extracellular region • axon • glutamatergic synapse • integral component of postsynaptic membrane Prosesau biolegol • sympathetic ganglion development • cell differentiation • semaphorin-plexin signaling pathway involved in neuron projection guidance • positive regulation of endothelial cell proliferation • vascular endothelial growth factor signaling pathway • nervous system development • axon guidance • positive regulation of endothelial cell migration • multicellular organism development • sympathetic neuron projection guidance • vascular endothelial growth factor receptor signaling pathway • cell adhesion • angiogenesis • nerve development • sympathetic neuron projection extension • axon extension involved in axon guidance • outflow tract septum morphogenesis • neural crest cell migration • neuron migration • heart development • facial nerve structural organization • vestibulocochlear nerve structural organization • gonadotrophin-releasing hormone neuronal migration to the hypothalamus • ventral trunk neural crest cell migration • negative chemotaxis • trigeminal ganglion development • sensory neuron axon guidance • neural crest cell migration involved in autonomic nervous system development • facioacoustic ganglion development • dorsal root ganglion morphogenesis • cellular response to leukemia inhibitory factor • regulation of postsynapse organization • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8828	n/a
Ensembl	ENSG00000118257	n/a
UniProt	O60462	n/a
RefSeq (mRNA)	NM_003872 NM_018534 NM_201264 NM_201266 NM_201267 NM_201279	n/a
RefSeq (protein)	NP_003863 NP_061004 NP_957716 NP_957718 NP_957719 NP_958436	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NRP2.

• NP2
• NPN2
• PRO2714
• VEGF165R2

Llyfryddiaeth

• "Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. ". Mol Cancer. 2015. PMID 25890345.
• "Molecular magnetic resonance probe targeting VEGF165: preparation and in vitro and in vivo evaluation. ". Contrast Media Mol Imaging. 2014. PMID 24729581.
• "The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer. ". Sci Signal. 2017. PMID 28096505.
• "Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation. ". J Pathol. 2016. PMID 27063000.
• "Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology.". Cancer Res. 2016. PMID 26560516.