NTF3

Protein sy'n cael ei godio yn y corff dynol gan y genyn NTF3 yw NTF3 a elwir hefyd yn Neurotrophin 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.31.

NTF3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B8K, 1BND, 1NT3, 3BUK
Dynodwyr
Cyfenwau	NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
Dynodwyr allanol	OMIM: 162660 HomoloGene: 1896 GeneCards: NTF3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • neurotrophin p75 receptor binding • neurotrophin receptor binding • chemoattractant activity • growth factor activity • signaling receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • GO:0016023 cytoplasmic vesicle • extracellular region • extracellular space • synaptic vesicle • axon • dendrite Prosesau biolegol • regulation of apoptotic process • GO:1904089 negative regulation of neuron apoptotic process • regulation of neuron differentiation • activation of protein kinase B activity • neuron projection morphogenesis • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • positive regulation of receptor internalization • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • cell-cell signaling • positive regulation of peptidyl-serine phosphorylation • induction of positive chemotaxis • negative regulation of peptidyl-tyrosine phosphorylation • positive regulation of cell population proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of actin cytoskeleton reorganization • GO:0072468 signal transduction • positive chemotaxis • nervous system development • regulation of signaling receptor activity • positive regulation of phospholipase C activity • positive regulation of phosphatidylinositol 3-kinase signaling • peripheral nervous system development • Cof • nerve development • nerve growth factor signaling pathway • modulation of chemical synaptic transmission • positive regulation of neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4908	n/a
Ensembl	ENSG00000185652	n/a
UniProt	P20783	n/a
RefSeq (mRNA)	NM_001102654 NM_002527	n/a
RefSeq (protein)	NP_001096124 NP_002518	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NTF3.

• NT3
• HDNF
• NGF2
• NT-3
• NGF-2

Llyfryddiaeth

• "Roles of neurotrophins in skeletal tissue formation and healing. ". J Cell Physiol. 2018. PMID 28370021.
• "Polymorphisms of the neurotrophic factor-3 (NTF-3) in Alzheimer's disease: rs6332 associated with onset time and rs6489630 T allele exhibited a protective role. ". J Neurogenet. 2015. PMID 26814132.
• "Survival, differentiation, and neuroprotective mechanisms of human stem cells complexed with neurotrophin-3-releasing pharmacologically active microcarriers in an ex vivo model of Parkinson's disease. ". Stem Cells Transl Med. 2015. PMID 25925835.
• "Neurotrophin 3 genotype and emotional adverse effects of osmotic-release oral system methylphenidate (OROS-MPH) in children with attention-deficit/hyperactivity disorder. ". J Psychopharmacol. 2014. PMID 23471121.
• "Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease.". Dement Geriatr Cogn Disord. 2012. PMID 23075484.