NUDT1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NUDT1 yw NUDT1 a elwir hefyd yn Nudix hydrolase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p22.3.

NUDT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IRY, 3Q93, 3WHW, 3ZR0, 3ZR1, 4C9W, 4C9X, 4N1T, 4N1U, 5ANS, 5ANW, 5ANV, 5ANU, 5ANT, 5FSN, 5FSI
Dynodwyr
Cyfenwau	NUDT1, MTH1, nudix hydrolase 1, human MutT homolog 1 (hMTH1), 8-oxo-dGTPase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxoguanine DNA glycolase
Dynodwyr allanol	OMIM: 600312 HomoloGene: 1839 GeneCards: NUDT1
EC number	3.6.1.56
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • m7G(5')pppN diphosphatase activity • ATP diphosphatase activity • 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • RNA binding • hydrolase activity • GTP diphosphatase activity • snoRNA binding • 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity • GO:0006184 GTPase activity Cydrannau o'r gell • cytoplasm • mitochondrial matrix • mitocondria • cnewyllyn cell • nuclear membrane • Cellbilen • acrosomal vesicle • extracellular space • cytosol Prosesau biolegol • nucleobase-containing small molecule catabolic process • dATP catabolic process • purine nucleotide catabolic process • DNA protection • GO:0001306 response to oxidative stress • dGTP catabolic process • GO:0100026 DNA repair • response to cadmium ion • GO:0010260 heneiddio • male gonad development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4521	n/a
Ensembl	ENSG00000106268	n/a
UniProt	P36639	n/a
RefSeq (mRNA)	NM_198954 NM_002452 NM_198948 NM_198949 NM_198950 NM_198952 NM_198953 NM_001367553 NM_001367554 NM_001367555	n/a
RefSeq (protein)	NP_002443 NP_945186 NP_945187 NP_945188 NP_945190 NP_945191 NP_945192 NP_001354482 NP_001354483 NP_001354484	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NUDT1.

• MTH1

Llyfryddiaeth

• "Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity. ". J Biol Chem. 2017. PMID 28035004.
• "Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma. ". Cancer Med. 2017. PMID 27917618.
• "Validation and development of MTH1 inhibitors for treatment of cancer. ". Ann Oncol. 2016. PMID 27827301.
• "Investigation of MTH1 activity via mismatch-based DNA chain elongation. ". Anal Chim Acta. 2016. PMID 26755138.
• "Investigation of micronucleus induction in MTH1 knockdown cells exposed to UVA, UVB or UVC.". Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID 26520386.