NUP98

Protein sy'n cael ei godio yn y corff dynol gan y genyn NUP98 yw NUP98 a elwir hefyd yn Nuclear pore complex protein Nup98-Nup96 a Nucleoporin 98 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.4.

NUP98
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KO6, 2Q5X, 2Q5Y, 3MMY, 4OWR, 5A9Q
Dynodwyr
Cyfenwau	NUP98, ADIR2, NUP196, NUP96, nucleoporin 98kDa, nucleoporin 98
Dynodwyr allanol	OMIM: 601021 HomoloGene: 35472 GeneCards: NUP98
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transporter activity • peptide binding • GO:0001948, GO:0016582 protein binding • nuclear localization sequence binding • RNA binding • GO:0070122 peptidase activity • serine-type peptidase activity • hydrolase activity • GO:0001105 transcription coactivator activity • mRNA binding • promoter-specific chromatin binding • GO:0005487 structural constituent of nuclear pore Cydrannau o'r gell • cytosol • nuclear membrane • nuclear envelope • nuclear periphery • bilen • nuclear pore • nuclear pore outer ring • nuclear inclusion body • nuclear pore nuclear basket • cnewyllyn cell • kinetochore • nuclear pore cytoplasmic filaments • nucleoplasm • intracellular membrane-bounded organelle • nuclear body • ribonucleoprotein complex • host cell Prosesau biolegol • mRNA transport • nuclear pore complex assembly • DNA replication • protein transport • GO:0022415 viral process • nuclear pore organization • posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery • RNA export from nucleus • telomere tethering at nuclear periphery • mRNA export from nucleus • protein import into nucleus • proteolysis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of mRNA splicing, via spliceosome • transcription by RNA polymerase II • nucleocytoplasmic transport • positive regulation of nucleic acid-templated transcription • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • GO:1905616 regulation of gene silencing by miRNA • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4928	n/a
Ensembl	ENSG00000110713	n/a
UniProt	P52948	n/a
RefSeq (mRNA)	NM_005387 NM_016320 NM_139131 NM_139132	n/a
RefSeq (protein)	NP_005378 NP_057404 NP_624357 NP_624358 NP_001352054 NP_001352055 NP_001352056 NP_001352057 NP_001352058	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NUP98.

• ADIR2
• NUP96
• NUP196

Llyfryddiaeth

• "NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis. ". Leukemia. 2017. PMID 27694926.
• "Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype. ". PLoS One. 2016. PMID 27031510.
• "NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern. ". Leukemia. 2013. PMID 23531517.
• "Dynamic association of NUP98 with the human genome. ". PLoS Genet. 2013. PMID 23468646.
• "A rare but specific subset of adult AML patients can be defined by the cytogenetically cryptic NUP98-NSD1 fusion gene.". Leukemia. 2013. PMID 22945772.