OASL

Protein sy'n cael ei godio yn y corff dynol gan y genyn OASL yw OASL a elwir hefyd yn 2'-5'-oligoadenylate synthase-like protein a 2'-5'-oligoadenylate synthetase like (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.31.

OASL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WH3, 4XQ7
Dynodwyr
Cyfenwau	OASL, OASLd, TRIP-14, TRIP14, p59 p59-p592'-5'-oligoadenylate synthetase like, OASL1
Dynodwyr allanol	OMIM: 603281 HomoloGene: 2769 GeneCards: OASL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • thyroid hormone receptor binding • 2'-5'-oligoadenylate synthetase activity • double-stranded RNA binding • ATP binding • RNA binding Cydrannau o'r gell • cytoplasm • bilen • nucleolus • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • immune system process • interferon-gamma-mediated signaling pathway • response to virus • negative regulation of viral genome replication • type I interferon signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • innate immune response • defense response to virus • regulation of ribonuclease activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8638	n/a
Ensembl	ENSG00000135114	n/a
UniProt	Q15646	n/a
RefSeq (mRNA)	NM_198213 NM_001261825 NM_003733 NM_001395418 NM_001395419	n/a
RefSeq (protein)	NP_001248754 NP_003724 NP_937856	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn OASL.

• OASL1
• OASLd
• TRIP14
• TRIP-14
• p59OASL
• p59*OASL
• p59-OASL

Llyfryddiaeth

• "The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. ". Genomics. 1999. PMID 10087211.
• "Selective inhibition of the dnase activity of the recBC enzyme by the DNA binding protein from Escherichia coli. ". J Biol Chem. 1976. PMID r 776974 r.
• "2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1. ". J Virol. 2015. PMID 26178980.
• "Identification of OASL d, a splice variant of human OASL, with antiviral activity. ". Int J Biochem Cell Biol. 2012. PMID 22531715.
• "Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C.". J Hepatol. 2008. PMID 18571276.