OGT

Protein sy'n cael ei godio yn y corff dynol gan y genyn OGT yw OGT a elwir hefyd yn O-linked N-acetylglucosamine (GlcNAc) transferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq13.1.

OGT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1W3B, 3PE3, 3PE4, 3TAX, 4AY5, 4AY6, 4CDR, 4GYW, 4GYY, 4GZ3, 4GZ5, 4GZ6, 4N39, 4N3A, 4N3B, 4XI9, 4XIF, 5BNW, 5C1D
Dynodwyr
Cyfenwau	OGT, HRNT1, O-GLCNAC, HINCUT-1, O-linked N-acetylglucosamine (GlcNAc) transferase, OGT1, MRX106, XLID106
Dynodwyr allanol	OMIM: 300255 HomoloGene: 9675 GeneCards: OGT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lipid binding • transferase activity • acetylglucosaminyltransferase activity • glycosyltransferase activity • histone acetyltransferase activity (H4-K8 specific) • histone acetyltransferase activity (H4-K5 specific) • protein O-GlcNAc transferase activity • GO:0001948, GO:0016582 protein binding • histone acetyltransferase activity (H4-K16 specific) • phosphatidylinositol-3,4,5-trisphosphate binding • protein N-acetylglucosaminyltransferase activity Cydrannau o'r gell • cytoplasm • bilen • Cellbilen • mitocondria • histone acetyltransferase complex • cnewyllyn cell • cytosol • nucleoplasm • GO:0009327 protein-containing complex • mitochondrial membranes • cell projection • protein N-acetylglucosaminyltransferase complex Prosesau biolegol • response to nutrient • proses rythmig • histone H3-K4 trimethylation • protein O-linked glycosylation • regulation of Rac protein signal transduction • circadian regulation of gene expression • regulation of glycolytic process • histone H4-K5 acetylation • response to insulin • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • positive regulation of proteolysis • positive regulation of histone H3-K27 methylation • histone H4-K16 acetylation • histone H4-K8 acetylation • phosphatidylinositol-mediated signaling • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:1903104 regulation of insulin receptor signaling pathway • GO:0097285 apoptotic process • protein deubiquitination • protein processing • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of protein ubiquitination • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • regulation of gluconeogenesis • GO:0022415 viral process • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8473	n/a
Ensembl	ENSG00000147162	n/a
UniProt	O15294	n/a
RefSeq (mRNA)	NM_003605 NM_181672 NM_181673 NM_025192	n/a
RefSeq (protein)	NP_858058 NP_858059	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn OGT.

• OGT1
• HRNT1
• MRX106
• HINCUT-1
• O-GLCNAC

Llyfryddiaeth

• "O-GlcNAcylation is associated with the development and progression of gastric carcinoma. ". Pathol Res Pract. 2016. PMID 27131860.
• "Human RNA Polymerase II Promoter Recruitment in Vitro Is Regulated by O-Linked N-Acetylglucosaminyltransferase (OGT). ". J Biol Chem. 2016. PMID 27129214.
• "Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability. ". J Biol Chem. 2017. PMID 28584052.
• "Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability. ". J Biol Chem. 2017. PMID 28302723.
• "Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.". J Biol Chem. 2017. PMID 28100784.