OPRK1

Protein sy'n cael ei godio yn y corff dynol gan y genyn OPRK1 yw OPRK1 a elwir hefyd yn Opioid receptor kappa 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q11.23.

OPRK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4DJH
Dynodwyr
Cyfenwau	OPRK1, K-OR-1, KOR, KOR-1, OPRK, opioid receptor kappa 1, KOR1, KOP
Dynodwyr allanol	OMIM: 165196 HomoloGene: 20253 GeneCards: OPRK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • neuropeptide binding • signal transducer activity • G protein-coupled opioid receptor activity • GO:0001948, GO:0016582 protein binding • dynorphin receptor activity • receptor serine/threonine kinase binding • peptide binding Cydrannau o'r gell • axon terminus • integral component of membrane • perikaryon • bilen • synapse • integral component of plasma membrane • neuronal cell body • dendrite • neuron projection • cnewyllyn cell • cytosol • Cellbilen • integral component of synaptic vesicle membrane • integral component of postsynaptic membrane • integral component of presynaptic membrane Prosesau biolegol • positive regulation of p38MAPK cascade • adwaith i gocên • negative regulation of luteinizing hormone secretion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • sensory perception • regulation of sensory perception of pain • eating behavior • locomotory behavior • behavioral response to cocaine • sensory perception of temperature stimulus • estrous cycle • conditioned place preference • response to estrogen • response to insulin • phospholipase C-activating G protein-coupled receptor signaling pathway • response to morphine • regulation of saliva secretion • positive regulation of dopamine secretion • G protein-coupled opioid receptor signaling pathway • defense response to virus • maternal behavior • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • response to acrylamide • positive regulation of potassium ion transmembrane transport • sensory perception of pain • response to radiation • response to ethanol • neuropeptide signaling pathway • cellular response to lipopolysaccharide • positive regulation of locomotion • GO:0072468 signal transduction • adenylate cyclase-inhibiting opioid receptor signaling pathway • chemical synaptic transmission • G protein-coupled receptor signaling pathway • GO:0035737 animal behaviour • positive regulation of eating behavior • cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4986	n/a
Ensembl	ENSG00000082556	n/a
UniProt	P41145	n/a
RefSeq (mRNA)	NM_001282904 NM_000912 NM_001318497	n/a
RefSeq (protein)	NP_000903 NP_001269833 NP_001305426	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn OPRK1.

• KOR
• OPRK
• KOR-1
• K-OR-1

Llyfryddiaeth

• "Molecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI. ". Sci Rep. 2016. PMID 26742690.
• "NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor. ". Proc Natl Acad Sci U S A. 2015. PMID 26372966.
• "OPRK1 promoter hypermethylation increases the risk of Alzheimer's disease. ". Neurosci Lett. 2015. PMID 26300544.
• "Identification and verification of proteins interacting with the kappa opioid receptor (KOPR). ". Methods Mol Biol. 2015. PMID 25293321.
• "Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology.". JAMA Psychiatry. 2014. PMID 25229257.