OSBPL8

Protein sy'n cael ei godio yn y corff dynol gan y genyn OSBPL8 yw OSBPL8 a elwir hefyd yn Oxysterol-binding protein-related protein 8 ac Oxysterol-binding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q21.2.

OSBPL8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1V88
Dynodwyr
Cyfenwau	OSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
Dynodwyr allanol	OMIM: 606736 HomoloGene: 68813 GeneCards: OSBPL8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylserine binding • cholesterol binding • phosphatidylinositol-4-phosphate binding • lipid binding • phospholipid transporter activity • sterol transporter activity • sterol binding Cydrannau o'r gell • integral component of membrane • nuclear membrane • endoplasmic reticulum membrane • bilen • cortical endoplasmic reticulum • Reticwlwm endoplasmig • cnewyllyn cell • cytosol • intracellular membrane-bounded organelle Prosesau biolegol • activation of protein kinase B activity • positive regulation of protein kinase B signaling • lipid transport • protein localization to nuclear pore • phospholipid transport • negative regulation of cell migration • negative regulation of sequestering of triglyceride • GO:1903106 positive regulation of insulin receptor signaling pathway • fat cell differentiation • phosphatidylserine acyl-chain remodeling • GO:0015915 transport • sterol transport • positive regulation of glucose import Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	114882	n/a
Ensembl	ENSG00000091039	n/a
UniProt	Q9BZF1	n/a
RefSeq (mRNA)	NM_001003712 NM_020841 NM_001319652 NM_001319653 NM_001319655	n/a
RefSeq (protein)	NP_001003712 NP_001306581 NP_001306582 NP_001306584 NP_065892	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn OSBPL8.

• ORP8
• MST120
• OSBP10
• MSTP120

Llyfryddiaeth

• "OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. ". Exp Cell Res. 2014. PMID 24424245.
• "ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function. ". EMBO Rep. 2016. PMID 27113756.
• "Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis. ". Oncol Res. 2017. PMID 27983927.
• "Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol. ". J Lipid Res. 2016. PMID 27530118.
• "Oxysterol-binding protein-related protein 8 (ORP8) increases sensitivity of hepatocellular carcinoma cells to Fas-mediated apoptosis.". J Biol Chem. 2015. PMID 25596532.