PCK1

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCK1 yw PCK1 a elwir hefyd yn Phosphoenolpyruvate carboxykinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.31.

PCK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
Dynodwyr
Cyfenwau	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
Dynodwyr allanol	OMIM: 614168 HomoloGene: 1944 GeneCards: PCK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • manganese ion binding • GDP binding • phosphoenolpyruvate carboxykinase activity • GTP binding • metal ion binding • carboxylic acid binding • purine nucleotide binding • lyase activity • carboxy-lyase activity • magnesium ion binding • phosphoenolpyruvate carboxykinase (GTP) activity Cydrannau o'r gell • cytoplasm • cytosol • extracellular exosome Prosesau biolegol • glucose homeostasis • internal protein amino acid acetylation • lipid metabolism • response to activity • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH • oxaloacetate metabolic process • response to insulin • glyceroneogenesis • cellular response to potassium ion starvation • cellular response to retinoic acid • response to lipid • cellular response to hypoxia • cellular response to fructose stimulus • response to interleukin-6 • glucose metabolic process • GO:0010260 heneiddio • response to methionine • cellular response to interleukin-1 • cellular response to glucagon stimulus • cellular response to cAMP • cellular response to insulin stimulus • cellular response to tumor necrosis factor • response to lipopolysaccharide • gluconeogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5105	n/a
Ensembl	ENSG00000124253	n/a
UniProt	P35558	n/a
RefSeq (mRNA)	NM_002591	n/a
RefSeq (protein)	NP_002582	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCK1.

• PCKDC
• PEPCK1
• PEPCKC
• PEPCK-C

Llyfryddiaeth

• "Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. ". Mol Genet Metab. 2014. PMID 24863970.
• "Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects. ". Clin Nutr. 2013. PMID 23092637.
• "Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction. ". Mol Genet Metab. 2017. PMID 28216384.
• "Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis. ". Mol Genet Metab. 2016. PMID 26971250.
• "Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft.". PLoS One. 2015. PMID 26528723.