PDCD4

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDCD4 yw PDCD4 a elwir hefyd yn Programmed cell death protein 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.2.

PDCD4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ
Dynodwyr
Cyfenwau	PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
Dynodwyr allanol	OMIM: 608610 HomoloGene: 7879 GeneCards: PDCD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • RNA binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • cytosol • nucleoplasm Prosesau biolegol • regulation of protein metabolic process • negative regulation of cell cycle • negative regulation of apoptotic process • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of JUN kinase activity • positive regulation of smooth muscle cell apoptotic process • negative regulation of myofibroblast differentiation • GO:0097285 apoptotic process • positive regulation of endothelial cell apoptotic process • BMP signaling pathway • epithelial to mesenchymal transition involved in cardiac fibroblast development • negative regulation of vascular associated smooth muscle cell differentiation • positive regulation of inflammatory response • cellular response to lipopolysaccharide • negative regulation of cytokine production involved in inflammatory response • positive regulation of NIK/NF-kappaB signaling • interleukin-12-mediated signaling pathway • negative regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	27250	n/a
Ensembl	ENSG00000150593	n/a
UniProt	Q53EL6	n/a
RefSeq (mRNA)	NM_145341 NM_001199492 NM_014456	n/a
RefSeq (protein)	NP_001186421 NP_055271 NP_663314	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDCD4.

• H731

Llyfryddiaeth

• "Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer. ". Oncol Res. 2016. PMID 26802652.
• "Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. ". Breast Cancer Res Treat. 2015. PMID 26026468.
• "The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis. ". Chin J Cancer. 2016. PMID 27852288.
• "Hypermethylation and Expression Silencing of PDCD4 Gene in Hepatocellular Carcinoma: A Consort Study. ". Medicine (Baltimore). 2016. PMID 26871813.
• "Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome.". Fertil Steril. 2016. PMID 26868993.