PDE5A

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE5A yw PDE5A a elwir hefyd yn Phosphodiesterase 5A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q26.

PDE5A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4OEX, 1RKP, 1T9R, 1T9S, 1TBF, 1UDT, 1UDU, 1UHO, 1XOZ, 1XP0, 2CHM, 2H40, 2H42, 2H44, 2XSS, 3B2R, 3BJC, 3HC8, 3HDZ, 3JWQ, 3JWR, 3LFV, 3MF0, 3SHY, 3SHZ, 3SIE, 3TGE, 3TGG, 4G2W, 4G2Y, 4I9Z, 4IA0, 4MD6, 4OEW
Dynodwyr
Cyfenwau	PDE5A, CGB-PDE, CN5A, PDE5, phosphodiesterase 5A
Dynodwyr allanol	OMIM: 603310 HomoloGene: 842 GeneCards: PDE5A
EC number	3.1.4.35
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • cGMP binding • metal ion binding • cyclic-nucleotide phosphodiesterase activity • catalytic activity • phosphoric diester hydrolase activity • hydrolase activity • 3',5'-cyclic-GMP phosphodiesterase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytosol • cydran cellog Prosesau biolegol • positive regulation of MAP kinase activity • cGMP metabolic process • positive regulation of cardiac muscle hypertrophy • cGMP catabolic process • negative regulation of T cell proliferation • positive regulation of oocyte development • metabolaeth • relaxation of cardiac muscle • GO:0072468 signal transduction • negative regulation of cardiac muscle contraction • regulation of nitric oxide mediated signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8654	n/a
Ensembl	ENSG00000138735	n/a
UniProt	O76074	n/a
RefSeq (mRNA)	NM_033437 NM_001083 NM_033430	n/a
RefSeq (protein)	NP_001074 NP_236914 NP_246273	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE5A.

• CN5A
• PDE5
• CGB-PDE

Llyfryddiaeth

• "Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome. ". Oncotarget. 2017. PMID 28099939.
• "PDE5A Polymorphisms Influence on Sildenafil Treatment Success. ". J Sex Med. 2016. PMID 27235284.
• "PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease. ". J Alzheimers Dis. 2016. PMID 26967220.
• "PDE5 expression in human thyroid tumors and effects of PDE5 inhibitors on growth and migration of cancer cells. ". Endocrine. 2015. PMID 25837309.
• "Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage.". Am J Psychiatry. 2015. PMID 25322361.