PF4

Protein sy'n cael ei godio yn y corff dynol gan y genyn PF4 yw PF4 a elwir hefyd yn Platelet factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q13.3.

PF4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
Dynodwyr
Cyfenwau	PF4, CXCL4, PF-4, SCYB4, platelet factor 4
Dynodwyr allanol	OMIM: 173460 HomoloGene: 87791 GeneCards: PF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • platelet alpha granule lumen • extracellular space • cytoplasm • collagen-containing extracellular matrix Prosesau biolegol • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • positive regulation of macrophage differentiation • platelet degranulation • negative regulation of megakaryocyte differentiation • positive regulation of cAMP-mediated signaling • negative regulation of MHC class II biosynthetic process • leukocyte chemotaxis • chemotaxis • response to lipopolysaccharide • positive regulation of macrophage derived foam cell differentiation • GO:1901313 positive regulation of gene expression • regulation of cell population proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of tumor necrosis factor production • negative regulation of angiogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • inflammatory response • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cytolysis • platelet activation • defense response • positive regulation of neutrophil chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of megakaryocyte differentiation • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • neutrophil chemotaxis • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5196	n/a
Ensembl	ENSG00000163737	n/a
UniProt	P02776	n/a
RefSeq (mRNA)	NM_002619 NM_001363352	n/a
RefSeq (protein)	NP_002610 NP_001350281	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PF4.

• PF-4
• CXCL4
• SCYB4

Llyfryddiaeth

• "CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells. ". J Immunol. 2017. PMID 28515281.
• "Steroids Regulate CXCL4 in the Human Endometrium During Menstruation to Enable Efficient Endometrial Repair. ". J Clin Endocrinol Metab. 2017. PMID 28323919.
• "Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation. ". J Biol Chem. 2017. PMID 28115521.
• "Serum CXCL4 increase in primary Sjögren's syndrome characterizes patients with microvascular involvement and reduced salivary gland infiltration and lymph node involvement. ". Clin Rheumatol. 2016. PMID 27562035.
• "CXC chemokine ligand 4 (CXCL4) is predictor of tumour angiogenic activity and prognostic biomarker in non-small cell lung cancer (NSCLC) patients undergoing surgical treatment.". Biomarkers. 2016. PMID 27098116.