PLN

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLN yw PLN a elwir hefyd yn Phospholamban (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q22.31.

PLN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PLP, 1ZLL, 2HYN
Dynodwyr
Cyfenwau	PLN, CMD1P, CMH18, PLB, phospholamban
Dynodwyr allanol	OMIM: 172405 HomoloGene: 136758 GeneCards: PLN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0048551 enzyme inhibitor activity • ATPase binding • calcium channel regulator activity • GO:0001948, GO:0016582 protein binding • ATPase inhibitor activity • identical protein binding • protein homodimerization activity Cydrannau o'r gell • integral component of membrane • fesigl • endoplasmic reticulum membrane • bilen • mitochondrial membranes • sarcoplasmic reticulum • Reticwlwm endoplasmig • mitocondria • sarcoplasmic reticulum membrane • perinuclear region of cytoplasm • calcium ion-transporting ATPase complex • GO:0009327 protein-containing complex Prosesau biolegol • Notch signaling pathway • regulation of ryanodine-sensitive calcium-release channel activity • negative regulation of calcium ion binding • regulation of cardiac conduction • regulation of calcium ion transport • GO:0048553 negative regulation of catalytic activity • regulation of heart contraction • regulation of cytosolic calcium ion concentration • cardiac muscle tissue development • negative regulation of heart contraction • response to testosterone • regulation of the force of heart contraction • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • negative regulation of ATP-dependent activity • regulation of ATPase-coupled calcium transmembrane transporter activity • regulation of calcium ion import • response to zinc ion • cellular calcium ion homeostasis • regulation of relaxation of cardiac muscle • negative regulation of calcium ion transmembrane transporter activity • blood circulation • negative regulation of heart rate • negative regulation of calcium ion import • response to insulin • regulation of cardiac muscle cell contraction • negative regulation of ATPase-coupled calcium transmembrane transporter activity • negative regulation of calcium ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process • regulation of cardiac muscle cell membrane potential • regulation of the force of heart contraction by cardiac conduction • regulation of relaxation of muscle • negative regulation of calcium ion import into sarcoplasmic reticulum • protein homooligomerization • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • relaxation of cardiac muscle • calcium ion transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5350	n/a
Ensembl	ENSG00000198523	n/a
UniProt	P26678	n/a
RefSeq (mRNA)	NM_002667	n/a
RefSeq (protein)	NP_002658	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLN.

• PLB
• CMD1P
• CMH18

Llyfryddiaeth

• "Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates, aggresomes, and autophagic degradation. ". Histopathology. 2016. PMID 26970417.
• "Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies. ". Sci Rep. 2016. PMID 26917049.
• "Cervical cancer systemic inflammation score: a novel predictor of prognosis. ". Oncotarget. 2016. PMID 26885692.
• "Sudden Cardiac Arrest and Rare Genetic Variants in the Community. ". Circ Cardiovasc Genet. 2016. PMID 26800703.
• "Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.". Phys Chem Chem Phys. 2016. PMID 26673394.