PPARA

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPARA yw PPARA a elwir hefyd yn Peroxisome proliferator-activated receptor alpha a Peroxisome proliferator activated receptor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.31.

PPARA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT
Dynodwyr
Cyfenwau	PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha
Dynodwyr allanol	HomoloGene: 21047 GeneCards: PPARA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • ubiquitin conjugating enzyme binding • lipid binding • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • signaling receptor activity • GO:0032403 protein-containing complex binding • transcription coactivator binding • phosphatase binding • NFAT protein binding • MDM2/MDM4 family protein binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • fatty acid binding • nuclear receptor coactivator activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • RNA polymerase II transcription regulator complex Prosesau biolegol • lipoprotein metabolic process • negative regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of fatty acid beta-oxidation • negative regulation of glycolytic process • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • negative regulation of blood pressure • lipid metabolism • proses rythmig • wound healing • negative regulation of leukocyte cell-cell adhesion • GO:1901227 negative regulation of transcription by RNA polymerase II • fatty acid transport • negative regulation of protein binding • negative regulation of appetite • circadian regulation of gene expression • transcription, DNA-templated • fatty acid metabolic process • behavioral response to nicotine • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • response to insulin • heart development • intracellular receptor signaling pathway • negative regulation of transcription regulatory region DNA binding • negative regulation of sequestering of triglyceride • regulation of circadian rhythm • regulation of fatty acid metabolic process • epidermis development • regulation of gene expression • enamel mineralization • positive regulation of gluconeogenesis • transcription initiation from RNA polymerase II promoter • negative regulation of inflammatory response • negative regulation of macrophage derived foam cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • negative regulation of neuron death • positive regulation of fatty acid oxidation • regulation of lipid metabolic process • GO:0072468 signal transduction • multicellular organism development • hormone-mediated signaling pathway • cell differentiation • response to lipid • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cell growth involved in cardiac muscle cell development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5465	n/a
Ensembl	ENSG00000186951	n/a
UniProt	Q07869 Q86SF0	n/a
RefSeq (mRNA)	NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644 NM_001362872 NM_001362873 NM_001393941 NM_001393942 NM_001393943 NM_001393944 NM_001393945 NM_001393946 NM_001393947	n/a
RefSeq (protein)	NP_001001928 NP_005027 NP_001349801 NP_001349802	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPARA.

• PPAR
• NR1C1
• hPPAR
• PPARalpha

Llyfryddiaeth

• "Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions. ". J Diabetes. 2017. PMID 27863018.
• "Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis. ". Tohoku J Exp Med. 2016. PMID 27644403.
• "Potential involvement of PPAR α activation in diminishing the hepatoprotective effect of fenofibrate in NAFLD: Accuracy of non- invasive panel in determining the stage of liver fibrosis in rats. ". Biomed Pharmacother. 2017. PMID 27930988.
• "Hepatitis B virus upregulates host expression of α-1,2-mannosidases viathe PPARα pathway. ". World J Gastroenterol. 2016. PMID 27920474.
• "PPARγ targeted oral cancer treatment and additional utility of genomics analytic techniques.". Laryngoscope. 2017. PMID 27896820.