PPM1B

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPM1B yw PPM1B a elwir hefyd yn Protein phosphatase 1B a Protein phosphatase, Mg2+/Mn2+ dependent 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p21.

PPM1B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2P8E
Dynodwyr
Cyfenwau	PPM1B, PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase, Mg2+/Mn2+ dependent 1B
Dynodwyr allanol	OMIM: 603770 HomoloGene: 2027 GeneCards: PPM1B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • magnesium ion binding • manganese ion binding • protein serine/threonine phosphatase activity • phosphoprotein phosphatase activity • catalytic activity • cation binding • hydrolase activity • metal ion binding Cydrannau o'r gell • bilen • cytoplasm • nucleolus • cytosol • cnewyllyn cell Prosesau biolegol • GO:0016576 protein dephosphorylation • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of defense response to virus • N-terminal protein myristoylation • peptidyl-threonine dephosphorylation • negative regulation of interferon-beta production • negative regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5495	n/a
Ensembl	ENSG00000138032	n/a
UniProt	O75688	n/a
RefSeq (mRNA)	NM_001033556 NM_001033557 NM_002706 NM_177968 NM_177969	n/a
RefSeq (protein)	NP_001028729 NP_002697 NP_808907 NP_808908	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPM1B.

• PP2CB
• PP2CBETA
• PP2C-beta
• PPC2BETAX
• PP2C-beta-X

Llyfryddiaeth

• "The cloning expression and tissue distribution of human PP2Cbeta. ". FEBS Lett. 1998. PMID 9684878.
• "miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition. ". Tumour Biol. 2016. PMID 26494000.
• "PPM1B depletion induces premature senescence in human IMR-90 fibroblasts. ". Mech Ageing Dev. 2014. PMID 24674756.
• "Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. ". Sci Rep. 2013. PMID 23903585.
• "Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta.". J Mol Biol. 2001. PMID 11563908.