PRKCD

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCD yw PRKCD a elwir hefyd yn Protein kinase C delta type a Protein kinase C delta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p21.1.

PRKCD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2YUU, 1YRK
Dynodwyr
Cyfenwau	PRKCD, ALPS3, CVID9, MAY1, PKCD, nPKC-delta, protein kinase C delta
Dynodwyr allanol	OMIM: 176977 HomoloGene: 55963 GeneCards: PRKCD
EC number	2.7.10.2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • kinase activity • ATP binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase binding • enzyme binding • insulin receptor substrate binding • transferase activity • GO:0001948, GO:0016582 protein binding • calcium-independent protein kinase C activity • protein kinase binding • nucleotide binding • GO:0010577 enzyme activator activity • protein serine/threonine kinase activity • protein kinase C activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • cell-cell junction • perinuclear region of cytoplasm • cnewyllyn cell • nuclear matrix • Reticwlwm endoplasmig • extracellular exosome • Cellbilen • nucleoplasm • extracellular region • azurophil granule lumen Prosesau biolegol • intrinsic apoptotic signaling pathway in response to oxidative stress • termination of signal transduction • interferon-gamma-mediated signaling pathway • negative regulation of protein binding • positive regulation of endodeoxyribonuclease activity • platelet activation • protein phosphorylation • cellular senescence • GO:1903105 negative regulation of insulin receptor signaling pathway • positive regulation of sphingomyelin catabolic process • cell chemotaxis • cell cycle • negative regulation of inflammatory response • positive regulation of protein dephosphorylation • Fc-gamma receptor signaling pathway involved in phagocytosis • positive regulation of apoptotic signaling pathway • stimulatory C-type lectin receptor signaling pathway • cellular response to hydroperoxide • negative regulation of peptidyl-tyrosine phosphorylation • defense response to bacterium • negative regulation of MAP kinase activity • positive regulation of response to DNA damage stimulus • positive regulation of protein import into nucleus • interleukin-10 production • regulation of actin cytoskeleton organization • negative regulation of actin filament polymerization • regulation of mRNA stability • phosphorylation • protein stabilization • regulation of signaling receptor activity • negative regulation of filopodium assembly • cellular response to angiotensin • interleukin-12 production • peptidyl-threonine phosphorylation • positive regulation of ceramide biosynthetic process • neutrophil activation • GO:0007243 intracellular signal transduction • negative regulation of glial cell apoptotic process • negative regulation of platelet aggregation • positive regulation of phospholipid scramblase activity • B cell proliferation • immunoglobulin mediated immune response • positive regulation of glucosylceramide catabolic process • peptidyl-tyrosine phosphorylation • positive regulation of superoxide anion generation • activation of protein kinase activity • GO:0072468 signal transduction • cellular response to hydrogen peroxide • GO:0035404 peptidyl-serine phosphorylation • GO:0097285 apoptotic process • neutrophil degranulation • execution phase of apoptosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5580	n/a
Ensembl	ENSG00000163932	n/a
UniProt	Q05655	n/a
RefSeq (mRNA)	NM_006254 NM_212539 NM_001316327 NM_001354676 NM_001354678 NM_001354679 NM_001354680	n/a
RefSeq (protein)	NP_001303256 NP_006245 NP_997704 NP_001341605 NP_001341607 NP_001341608 NP_001341609	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCD.

• 37012
• PKCD
• ALPS3
• CVID9
• nPKC-delta

Llyfryddiaeth

• "Early-Onset Juvenile SLE Associated With a Novel Mutation in Protein Kinase C δ. ". Pediatrics. 2017. PMID 28003329.
• "Loss of PKCδ Induces Prostate Cancer Resistance to Paclitaxel through Activation of Wnt/β-Catenin Pathway and Mcl-1 Accumulation. ". Mol Cancer Ther. 2016. PMID 27196755.
• "PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. ". J Clin Invest. 2016. PMID 26808499.
• "PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65. ". Sci Rep. 2015. PMID 26218882.
• "Identification of proteins interacting with protein kinase C-δ in hyperthermia-induced apoptosis and thermotolerance of Tca8113 cells.". Mol Med Rep. 2015. PMID 26017369.