PTH

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTH yw PTH a elwir hefyd yn Parathyroid hormone (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.3.

PTH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BWX, 1ET1, 1FVY, 1HPH, 1HPY, 1HTH, 1ZWA, 1ZWB, 1ZWD, 1ZWE, 1ZWF, 1ZWG, 2L1X, 3C4M
Dynodwyr
Cyfenwau	PTH, PTH1, parathyroid hormone, Parathyroid hormone, FIH1
Dynodwyr allanol	OMIM: 168450 HomoloGene: 266 GeneCards: PTH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • hormone activity • parathyroid hormone receptor binding • type 1 parathyroid hormone receptor binding • protein N-terminus binding • receptor ligand activity • peptide hormone receptor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • intracellular anatomical structure • extracellular region • extracellular space Prosesau biolegol • positive regulation of signal transduction • positive regulation of cell proliferation in bone marrow • positive regulation of osteoclast proliferation • response to fibroblast growth factor • hormone-mediated apoptotic signaling pathway • cAMP metabolic process • response to ethanol • response to parathyroid hormone • skeletal system development • positive regulation of ossification • response to lead ion • response to nutrient levels • G protein-coupled receptor signaling pathway • response to vitamin D • negative regulation of apoptotic process in bone marrow cell • GO:1901227 negative regulation of transcription by RNA polymerase II • cellular macromolecule biosynthetic process • cellular calcium ion homeostasis • homeostasis of number of cells within a tissue • response to cadmium ion • Rho protein signal transduction • positive regulation of glucose import • positive regulation of glycogen biosynthetic process • bone resorption • positive regulation of bone mineralization • regulation of gene expression • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cell-cell signaling • activation of phospholipase C activity • negative regulation of chondrocyte differentiation • positive regulation of inositol phosphate biosynthetic process • negative regulation of bone mineralization involved in bone maturation • regulation of signaling receptor activity • adenylate cyclase-activating G protein-coupled receptor signaling pathway • calcium ion transport • magnesium ion homeostasis • bone mineralization • phosphate ion homeostasis • calcium ion homeostasis • negative regulation of calcium ion transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5741	n/a
Ensembl	ENSG00000152266	n/a
UniProt	P01270	n/a
RefSeq (mRNA)	NM_000315 NM_001316352	n/a
RefSeq (protein)	NP_000306 NP_001303281	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTH.

• PTH1

Llyfryddiaeth

• "Association of parathyroid hormone and vitamin D with untreated hypertension: Is it different in white-coat or sustained hypertension?". PLoS One. 2017. PMID 29176783.
• "Influence of concurrent chronic kidney disease on intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism. ". Surgery. 2018. PMID 29128188.
• "The effect of parathyroid hormone on the uptake and retention of 25-hydroxyvitamin D in skeletal muscle cells. ". J Steroid Biochem Mol Biol. 2017. PMID 28104493.
• "Adenomatous Colon Polyps in Diabetes: Increased Prevalence in Patients with Chronic Kidney Disease and Its Association with Parathyroid Hormone. ". Ann Clin Lab Sci. 2016. PMID 27993873.
• "Genetic Variants Associated with Circulating Parathyroid Hormone.". J Am Soc Nephrol. 2017. PMID 27927781.