PTK2B

PTK2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2LK4, 3CC6, 3ET7, 3FZO, 3FZP, 3FZR, 3FZS, 3FZT, 3GM1, 3GM2, 3GM3, 3H3C, 3U3F, 4EKU, 4H1J, 4H1M, 4R32, 4XEK, 4XEF, 4XEV
Dynodwyr
Cyfenwau	PTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK, protein tyrosine kinase 2 beta
Dynodwyr allanol	OMIM: 601212 HomoloGene: 23001 GeneCards: PTK2B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0032403 protein-containing complex binding; • kinase activity; • signaling receptor binding; • ATP binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • transferase activity; • GO:0001948, GO:0016582 protein binding; • nucleotide binding; • 3-phosphoinositide-dependent protein kinase binding; • NMDA glutamate receptor activity; • signal transducer activity; • calmodulin-dependent protein kinase activity; • enzyme binding; • protein tyrosine kinase activity; • ubiquitin protein ligase binding; • protein C-terminus binding;
Cydrannau o'r gell	• bilen; • focal adhesion; • extrinsic component of cytoplasmic side of plasma membrane; • NMDA selective glutamate receptor complex; • perinuclear region of cytoplasm; • Cytosgerbwd; • cnewyllyn cell; • cell projection; • membrane raft; • lamellipodium; • apical dendrite; • growth cone; • Cellbilen; • axon; • neuronal cell body; • cell cortex; • cell body; • GO:0097483, GO:0097481 postsynaptic density; • cell junction; • dendrite; • cytosol; • cytoplasm; • dendritic spine; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • cellular response to retinoic acid; • adaptive immune response; • positive regulation of actin filament polymerization; • tumor necrosis factor-mediated signaling pathway; • positive regulation of JNK cascade; • regulation of angiogenesis; • marginal zone B cell differentiation; • negative regulation of muscle cell apoptotic process; • positive regulation of translation; • stress fiber assembly; • negative regulation of ossification; • protein phosphorylation; • cell surface receptor signaling pathway; • vascular endothelial growth factor receptor signaling pathway; • regulation of cell adhesion; • positive regulation of reactive oxygen species metabolic process; • angiogenesis; • positive regulation of ERK1 and ERK2 cascade; • long-term depression; • positive regulation of excitatory postsynaptic potential; • regulation of cGMP-mediated signaling; • response to ethanol; • neuron projection development; • negative regulation of cell population proliferation; • adwaith i gocên; • GO:0097285 apoptotic process; • regulation of actin cytoskeleton reorganization; • GO:0051247, GO:0051200 positive regulation of protein metabolic process; • epidermal growth factor receptor signaling pathway; • actin filament organization; • GO:0001315 response to reactive oxygen species; • chemokine-mediated signaling pathway; • response to mechanical stimulus; • signal complex assembly; • bone resorption; • response to lithium ion; • response to osmotic stress; • positive regulation of cell growth; • positive regulation of nitric-oxide synthase activity; • positive regulation of synaptic transmission, glutamatergic; • ionotropic glutamate receptor signaling pathway; • response to organonitrogen compound; • positive regulation of DNA biosynthetic process; • positive regulation of peptidyl-tyrosine phosphorylation; • protein autophosphorylation; • innate immune response; • negative regulation of myeloid cell differentiation; • response to immobilization stress; • cell differentiation; • phosphorylation; • positive regulation of cell-matrix adhesion; • positive regulation of JUN kinase activity; • immune system process; • regulation of release of sequestered calcium ion into cytosol; • negative regulation of apoptotic process; • sprouting angiogenesis; • regulation of inositol trisphosphate biosynthetic process; • response to glucose; • cellular response to fluid shear stress; • positive regulation of angiogenesis; • response to calcium ion; • regulation of NMDA receptor activity; • cellular defense response; • oocyte maturation; • positive regulation of ubiquitin-dependent protein catabolic process; • negative regulation of potassium ion transport; • regulation of cell shape; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • positive regulation of B cell chemotaxis; • response to hormone; • response to cAMP; • regulation of nitric oxide biosynthetic process; • regulation of establishment of cell polarity; • response to hydrogen peroxide; • regulation of macrophage chemotaxis; • positive regulation of protein kinase activity; • regulation of leukocyte chemotaxis; • negative regulation of bone mineralization; • regulation of cell migration; • response to hypoxia; • blood vessel endothelial cell migration; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • positive regulation of cell migration; • regulation of bone mineralization; • positive regulation of cytosolic calcium ion concentration; • positive regulation of nitric oxide biosynthetic process; • response to stress; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of endothelial cell migration; • focal adhesion assembly; • regulation of cell population proliferation; • regulation of calcium-mediated signaling; • positive regulation of cell population proliferation; • positive regulation of neuron projection development; • glial cell proliferation; • activation of Janus kinase activity; • peptidyl-tyrosine phosphorylation; • regulation of ubiquitin-dependent protein catabolic process; • GO:0072468 signal transduction; • long-term potentiation; • cell adhesion; • interleukin-7-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • regulation of synaptic plasticity; • GO:0034622 protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	2185
	n/a
	ENSG00000120899
	n/a
	Q14289
	n/a
	NM_004103; NM_173174; NM_173175; NM_173176
	n/a
	NP_004094; NP_775266; NP_775267; NP_775268
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTK2B yw PTK2B a elwir hefyd yn Protein tyrosine kinase 2 beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTK2B.

PKB
PTK
CAKB
FAK2
PYK2
CADTK
FADK2
RAFTK

Llyfryddiaeth

"Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses. ". Neurosci Lett. 2016. PMID 27080426.
"A Dual Role for the Nonreceptor Tyrosine Kinase Pyk2 during the Intracellular Trafficking of Human Papillomavirus 16. ". J Virol. 2015. PMID 26109718.
"PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop. ". Oncotarget. 2015. PMID 26084289.
"Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner. ". J Biol Chem. 2015. PMID 25778396.
"Pyk2 promotes tumor progression in multiple myeloma.". Blood. 2014. PMID 25217697.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PTK2B - Cronfa NCBI

[2]

[1]