PTPN22

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPN22 yw PTPN22 a elwir hefyd yn Protein tyrosine phosphatase, non-receptor type 22 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.2.

PTPN22
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2P6X, 2QCJ, 2QCT, 3BRH, 3H2X, 3OLR, 3OMH, 4J51
Dynodwyr
Cyfenwau	PTPN22, protein tyrosine phosphatase, non-receptor type 22 (lymphoid), LYP, LYP1, LYP2, PEP, PTPN8, protein tyrosine phosphatase, non-receptor type 22, PTPN22.6, PTPN22.5, protein tyrosine phosphatase non-receptor type 22
Dynodwyr allanol	OMIM: 600716 HomoloGene: 7498 GeneCards: PTPN22
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • SH3 domain binding • GO:0098519, GO:0098518 phosphatase activity • kinase binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • ubiquitin protein ligase binding • protein tyrosine phosphatase activity Cydrannau o'r gell • cytoplasm • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • cnewyllyn cell • cytosol Prosesau biolegol • positive regulation of protein K63-linked ubiquitination • regulation of NIK/NF-kappaB signaling • regulation of innate immune response • regulation of natural killer cell proliferation • positive regulation of toll-like receptor 3 signaling pathway • regulation of T cell receptor signaling pathway • regulation of B cell receptor signaling pathway • phosphoanandamide dephosphorylation • immune system process • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • negative regulation of p38MAPK cascade • GO:0016576 protein dephosphorylation • negative regulation of gene expression • negative regulation of T cell receptor signaling pathway • cellular response to muramyl dipeptide • autophagy • response to lipopolysaccharide • T cell differentiation • GO:1901313 positive regulation of gene expression • positive regulation of ERK1 and ERK2 cascade • positive regulation of toll-like receptor 4 signaling pathway • negative regulation of tumor necrosis factor production • negative regulation of autophagy • negative regulation of JUN kinase activity • negative regulation of T cell activation • positive regulation of type I interferon production • lipopolysaccharide-mediated signaling pathway • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • peptidyl-tyrosine dephosphorylation • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26191	n/a
Ensembl	ENSG00000134242	n/a
UniProt	Q9Y2R2	n/a
RefSeq (mRNA)	NM_001193431 NM_001308297 NM_012411 NM_015967	n/a
RefSeq (protein)	NP_001180360 NP_001295226 NP_036543 NP_057051	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPN22.

• LYP
• PEP
• LYP1
• LYP2
• PTPN8
• PTPN22.5
• PTPN22.6

Llyfryddiaeth

• "[STUDY OF THE PTPN22 GENE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS IN THE AZERBAIJANI POPULATION]. ". Georgian Med News. 2017. PMID 29099700.
• "Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis. ". Einstein (Sao Paulo). 2017. PMID 28444099.
• "Association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T polymorphism and susceptibility to vitiligo: Systematic review and meta-analysis. ". Indian J Dermatol Venereol Leprol. 2017. PMID 28164884.
• "Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways. ". Biomed Pharmacother. 2017. PMID 27936393.
• "Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores.". Clin Immunol. 2016. PMID 27810512.