PTPRK

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRK yw PTPRK a elwir hefyd yn Receptor-type tyrosine-protein phosphatase kappa a Protein tyrosine phosphatase, receptor type K (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q22.33.

PTPRK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C7S
Dynodwyr
Cyfenwau	PTPRK, R-PTP-kappa, protein tyrosine phosphatase, receptor type K, protein tyrosine phosphatase receptor type K
Dynodwyr allanol	OMIM: 602545 HomoloGene: 55693 GeneCards: PTPRK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-catenin binding • phosphoprotein phosphatase activity • gamma-catenin binding • GO:0098519, GO:0098518 phosphatase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • protein kinase binding • hydrolase activity Cydrannau o'r gell • integral component of membrane • bilen • cell-cell junction • adherens junction • photoreceptor outer segment • integral component of plasma membrane • cell surface • axon • neuronal cell body • dendrite • leading edge membrane • Cellbilen • cell junction • intracellular membrane-bounded organelle Prosesau biolegol • negative regulation of keratinocyte proliferation • cellular response to UV • GO:0016576 protein dephosphorylation • negative regulation of cell cycle • GO:0072353 cellular response to reactive oxygen species • focal adhesion assembly • cell adhesion • negative regulation of cell migration • protein localization to cell surface • GO:0045996 negative regulation of transcription, DNA-templated • neuron projection development • transforming growth factor beta receptor signaling pathway • cell migration • GO:0072468 signal transduction • negative regulation of cell population proliferation • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5796	n/a
Ensembl	ENSG00000152894 ENSG00000273993	n/a
UniProt	Q15262	n/a
RefSeq (mRNA)	NM_001135648 NM_001291981 NM_001291982 NM_001291983 NM_001291984 NM_002844	n/a
RefSeq (protein)	NP_001129120 NP_001278910 NP_001278911 NP_001278912 NP_001278913 NP_002835	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRK.

• R-PTP-kappa

Llyfryddiaeth

• "Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation. ". Oncogene. 2015. PMID 24882578.
• "Receptor-like protein tyrosine phosphatase κ negatively regulates the apoptosis of prostate cancer cells via the JNK pathway. ". Int J Oncol. 2013. PMID 24002526.
• "Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors. ". Int J Oncol. 2017. PMID 28259897.
• "Notch and TGF-β pathways cooperatively regulate receptor protein tyrosine phosphatase-κ (PTPRK) gene expression in human primary keratinocytes. ". Mol Biol Cell. 2015. PMID 25609089.
• "TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.". Ann Rheum Dis. 2016. PMID 25378349.