PUM1

Protein sy'n cael ei godio yn y corff dynol gan y genyn PUM1 yw PUM1 a elwir hefyd yn Pumilio homolog 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p35.2.

PUM1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IB2, 1M8W, 1M8X, 1M8Y, 1M8Z, 2YJY, 3BSB, 3BSX, 3Q0L, 3Q0M, 3Q0N, 3Q0O, 3Q0P
Dynodwyr
Cyfenwau	PUM1, HSPUM, PUMH, PUMH1, PUML1, pumilio RNA binding family member 1, SCA47
Dynodwyr allanol	OMIM: 607204 HomoloGene: 22830 GeneCards: PUM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • mRNA 3'-UTR binding • GO:0001948, GO:0016582 protein binding • RNA binding • miRNA binding Cydrannau o'r gell • cytoplasm • P-body • cytoplasmic stress granule • cnewyllyn cell • nucleoplasm • cytosol • nuclear speck Prosesau biolegol • GO:1905616 regulation of gene silencing by miRNA • cell differentiation • regulation of mRNA stability • adult locomotory behavior • GO:1905618 positive regulation of gene silencing by miRNA • stem cell differentiation • regulation of cell cycle • posttranscriptional gene silencing • regulation of chromosome segregation • positive regulation of RIG-I signaling pathway • mRNA destabilization • spermatogenesis • regulation of translation • posttranscriptional regulation of gene expression • production of miRNAs involved in gene silencing by miRNA Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9698	n/a
Ensembl	ENSG00000134644	n/a
UniProt	Q14671	n/a
RefSeq (mRNA)	NM_014676 NM_001020658	n/a
RefSeq (protein)	NP_001018494 NP_055491	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PUM1.

• PUMH
• HSPUM
• PUMH1
• PUML1

Llyfryddiaeth

• "The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?". IUBMB Life. 2003. PMID 14584586.
• "Crystal structure of a Pumilio homology domain. ". Mol Cell. 2001. PMID 11336708.
• "Upregulated hPuf-A promotes breast cancer tumorigenesis. ". Tumour Biol. 2013. PMID 23625657.
• "Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. ". Structure. 2008. PMID 18328718.
• "Identification of genes for normalization of real-time RT-PCR data in breast carcinomas.". BMC Cancer. 2008. PMID 18211679.