RAD52

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAD52 yw RAD52 a elwir hefyd yn DNA repair protein RAD52 homolog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.33.

RAD52
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H2I, 1KN0
Dynodwyr
Cyfenwau	RAD52, RAD52 homolog, DNA repair protein
Dynodwyr allanol	OMIM: 600392 HomoloGene: 31118 GeneCards: RAD52
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001948, GO:0016582 protein binding • single-stranded DNA binding • identical protein binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • protein-DNA complex • GO:0009327 protein-containing complex Prosesau biolegol • DNA double-strand break processing involved in repair via single-strand annealing • DNA recombinase assembly • cellular response to oxidative stress • DNA recombination • double-strand break repair via single-strand annealing • regulation of nucleotide-excision repair • double-strand break repair • cellular response to DNA damage stimulus • GO:0100026 DNA repair • double-strand break repair via homologous recombination • protein homooligomerization • mitotic recombination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5893	n/a
Ensembl	ENSG00000002016	n/a
UniProt	P43351	n/a
RefSeq (mRNA)	NM_001297419 NM_001297420 NM_001297421 NM_001297422 NM_134422 NM_134423 NM_134424	n/a
RefSeq (protein)	NP_001284348 NP_001284349 NP_001284350 NP_001284351 NP_602296	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Structure of the human DNA-repair protein RAD52 containing surface mutations. ". Acta Crystallogr F Struct Biol Commun. 2016. PMID 27487923.
• "Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. ". Mol Carcinog. 2016. PMID 26013599.
• "RAD52 gene polymorphisms are associated with risk of colorectal cancer in a Chinese Han population. ". Medicine (Baltimore). 2017. PMID 29245274.
• "Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair. ". DNA Repair (Amst). 2017. PMID 28549257.
• "Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination.". Cell Rep. 2017. PMID 28329678.