RARA

RARA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13
Dynodwyr
Cyfenwau	RARA, NR1B1, RAR, retinoic acid receptor alpha, RARalpha
Dynodwyr allanol	OMIM: 180240 HomoloGene: 20262 GeneCards: RARA
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• retinoic acid binding; • GO:0001106 transcription corepressor activity; • protein domain specific binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • mRNA 5'-UTR binding; • signaling receptor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • retinoic acid-responsive element binding; • transcription factor binding; • metal ion binding; • steroid hormone receptor activity; • enzyme binding; • zinc ion binding; • GO:0001948, GO:0016582 protein binding; • DNA binding; • sequence-specific DNA binding; • GO:0001105 transcription coactivator activity; • protein kinase A binding; • protein kinase B binding; • translation repressor activity, mRNA regulatory element binding; • alpha-actinin binding; • protein heterodimerization activity; • chromatin DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • GO:0000975 transcription cis-regulatory region binding; • nuclear receptor coactivator activity; • signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • actin cytoskeleton; • perinuclear region of cytoplasm; • neuron projection; • cnewyllyn cell; • cell surface; • nucleoplasm; • neuronal cell body; • dendrite; • cytosol; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• growth plate cartilage development; • germ cell development; • cellular response to retinoic acid; • ureteric bud development; • positive regulation of interleukin-5 production; • prostate gland development; • limb development; • apoptotic cell clearance; • chondroblast differentiation; • regulation of granulocyte differentiation; • protein phosphorylation; • response to vitamin A; • face development; • spermatogenesis; • response to ethanol; • negative regulation of cell population proliferation; • steroid hormone mediated signaling pathway; • regulation of apoptotic process; • response to cytokine; • negative regulation of translation; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cell differentiation; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to estrogen stimulus; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of cell cycle; • regulation of myelination; • positive regulation of neuron differentiation; • negative regulation of tumor necrosis factor production; • transcription initiation from RNA polymerase II promoter; • trachea cartilage development; • glandular epithelial cell development; • male gonad development; • negative regulation of cartilage development; • response to retinoic acid; • negative regulation of granulocyte differentiation; • multicellular organism growth; • female pregnancy; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of interleukin-4 production; • regulation of synaptic plasticity; • outflow tract septum morphogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of interferon-gamma production; • response to estradiol; • negative regulation of translational initiation; • embryonic camera-type eye development; • positive regulation of interleukin-13 production; • neural tube closure; • positive regulation of binding; • retinoic acid receptor signaling pathway; • GO:1901313 positive regulation of gene expression; • Sertoli cell fate commitment; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • ventricular cardiac muscle cell differentiation; • liver development; • cellular response to lipopolysaccharide; • bone development; • hippocampus development; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • multicellular organism development; • hormone-mediated signaling pathway; • cell differentiation; • response to lipid; • gland development; • bone morphogenesis; • epithelium development;
	Sources:Amigo / QuickGO
Orthologau
	5914
	n/a
	ENSG00000131759
	n/a
	P10276; Q6I9R7
	n/a
	NM_000964; NM_001024809; NM_001033603; NM_001145301; NM_001145302
	n/a
NP_000955; NP_001019980; NP_001138773; NP_001138774; NP_000955.1;
	NP_001138773.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RARA yw RARA a elwir hefyd yn RARA protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron golygu

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RARA.

RAR
NR1B1

Llyfryddiaeth golygu

"Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures. ". Mol Oncol. 2015. PMID 25300573.
"Expression and Subcellular Localization of Retinoic Acid Receptor-α (RARα) in Healthy and Varicocele Human Spermatozoa: Its Possible Regulatory Role in Capacitation and Survival. ". Appl Immunohistochem Mol Morphol. 2015. PMID 24992177.
"NLSâ€‘RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway. ". Mol Med Rep. 2016. PMID 27840989.
"RARα mediates all-trans-retinoic acid-induced VEGF-C, VEGF-D, and VEGFR3 expression in lung cancer cells. ". Cell Biol Int. 2016. PMID 26818829.
"All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage.". BMC Cancer. 2016. PMID 26728137.

Cyfeiriadau golygu

[1] "Human PubMed Reference:".

[2] RARA - Cronfa NCBI

[2]

[1]