RB1

Protein sy'n cael ei godio yn y corff dynol gan y genyn RB1 yw RB1 a elwir hefyd yn RB transcriptional corepressor 1 a Retinoblastoma 1 (Including osteosarcoma), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q14.2.

RB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4ELJ, 4ELL, 4CRI
Dynodwyr
Cyfenwau	RB1, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1, p110-RB1
Dynodwyr allanol	OMIM: 614041 HomoloGene: 272 GeneCards: RB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • transcription factor binding • phosphoprotein binding • kinase binding • GO:0001948, GO:0016582 protein binding • androgen receptor binding • identical protein binding • enzyme binding • ubiquitin protein ligase binding • importin-alpha family protein binding • disordered domain specific binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific Cydrannau o'r gell • PML body • SWI/SNF complex • transcription regulator complex • spindle • cyclin/CDK positive transcription elongation factor complex • chromatin • cnewyllyn cell • nucleoplasm • Rb-E2F complex Prosesau biolegol • negative regulation of cell population proliferation • negative regulation of mitotic cell cycle • neuron apoptotic process • androgen receptor signaling pathway • chromatin remodeling • negative regulation of smoothened signaling pathway • negative regulation of protein kinase activity • cell morphogenesis involved in neuron differentiation • mitotic cell cycle checkpoint signaling • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of macrophage differentiation • cellular response to xenobiotic stimulus • negative regulation of cell cycle • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • glial cell apoptotic process • regulation of cohesin loading • regulation of cell cycle • neuron maturation • Cellraniad • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • positive regulation of mitotic metaphase/anaphase transition • GO:1903097, GO:1903098, GO:1903099 regulation of centromere complex assembly • enucleate erythrocyte differentiation • neuron differentiation • regulation of mitotic cell cycle • negative regulation of epithelial cell proliferation • skeletal muscle cell differentiation • sister chromatid biorientation • protein localization to chromosome, centromeric region • cell cycle • striated muscle cell differentiation • Ras protein signal transduction • myoblast differentiation • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • neuron projection development • digestive tract development • maintenance of mitotic sister chromatid cohesion • regulation of lipid kinase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • hepatocyte apoptotic process • GO:0097285 apoptotic process • positive regulation of transcription regulatory region DNA binding • negative regulation of gene expression • regulation of cell growth • tissue homeostasis • GO:0009373 regulation of transcription, DNA-templated • G1/S transition of mitotic cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transcription involved in G1/S transition of mitotic cell cycle • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • aortic valve morphogenesis • negative regulation of inflammatory response • positive regulation of extracellular matrix organization • positive regulation of collagen fibril organization • negative regulation of myofibroblast differentiation • cell differentiation • negative regulation of cold-induced thermogenesis • negative regulation of protein serine/threonine kinase activity • negative regulation of tau-protein kinase activity • negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5925	n/a
Ensembl	ENSG00000139687	n/a
UniProt	P06400	n/a
RefSeq (mRNA)	NM_000321	n/a
RefSeq (protein)	NP_000312 NP_000312.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RB1.

• RB
• pRb
• OSRC
• pp110
• p105-Rb
• PPP1R130

Llyfryddiaeth

• "Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. ". Biomed Res Int. 2016. PMID 28101510.
• "Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids. ". Development. 2017. PMID 28087635.
• "Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation. ". Cancer Sci. 2017. PMID 28865172.
• "Defective splicing of the RB1 transcript is the dominant cause of retinoblastomas. ". Hum Genet. 2017. PMID 28780672.
• "Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling.". PLoS One. 2017. PMID 28575107.