RBFOX2

Protein sy'n cael ei godio yn y corff dynol gan y genyn RBFOX2 yw RBFOX2 a elwir hefyd yn RNA-binding protein fox-1 homolog 2 a RNA binding fox-1 homolog 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q12.3.

RBFOX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CQ3
Dynodwyr
Cyfenwau	RBFOX2, FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh, RNA binding protein, fox-1 homolog 2, RNA binding fox-1 homolog 2
Dynodwyr allanol	OMIM: 612149 HomoloGene: 49375 GeneCards: RBFOX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • transcription factor binding • GO:0001948, GO:0016582 protein binding • RNA binding • nucleic acid binding • mRNA binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • cytoplasm • cytosol Prosesau biolegol • neuromuscular process controlling balance • dendrite morphogenesis • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • nervous system development • regulation of RNA splicing • regulation of cell population proliferation • RNA splicing • radial glia guided migration of Purkinje cell • regulation of definitive erythrocyte differentiation • RNA metabolic process • GO:0045996 negative regulation of transcription, DNA-templated • intracellular estrogen receptor signaling pathway • fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23543	n/a
Ensembl	ENSG00000277564 ENSG00000100320	n/a
UniProt	O43251	n/a
RefSeq (mRNA)	NM_001031695 NM_001082576 NM_001082577 NM_001082578 NM_001082579 NM_014309 NM_001349982 NM_001349983 NM_001349989 NM_001349990 NM_001349991 NM_001349992 NM_001349994 NM_001349995 NM_001349996 NM_001349997 NM_001349998 NM_001349999 NM_001394108 NM_001394109 NM_001394110 NM_001394111 NM_001394112 NM_001394113 NM_001394114 NM_001394115	n/a
RefSeq (protein)	NP_001026865 NP_001076045 NP_001076046 NP_001076047 NP_001076048 NP_055124 NP_001336911 NP_001336912 NP_001336918 NP_001336919 NP_001336920 NP_001336921 NP_001336923 NP_001336924 NP_001336925 NP_001336926 NP_001336927 NP_001336928	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RBFOX2.

• RTA
• fxh
• FOX2
• RBM9
• Fox-2
• HNRBP2
• HRNBP2
• dJ106I20.3

Llyfryddiaeth

• "An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. ". Nat Struct Mol Biol. 2009. PMID 19136955.
• "RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. ". Mol Cell. 2016. PMID 27211866.
• "Aberrant Splicing Induced by Dysregulated Rbfox2 Produces Enhanced Function of CaV1.2 Calcium Channel and Vascular Myogenic Tone in Hypertension. ". Hypertension. 2017. PMID 28993448.
• "Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer. ". Nucleic Acids Res. 2016. PMID 27001519.
• "RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues.". Mol Cell Biol. 2013. PMID 23149937.