RGN

Protein sy'n cael ei godio yn y corff dynol gan y genyn RGN yw RGN a elwir hefyd yn Regucalcin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.3.

RGN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3G4E, 3G4H, 4GNB, 4GNC
Dynodwyr
Cyfenwau	RGN, GNL, HEL-S-41, RC, SMP30, regucalcin
Dynodwyr allanol	OMIM: 300212 HomoloGene: 3437 GeneCards: RGN
EC number	3.1.1.17
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • gluconolactonase activity • zinc ion binding • GO:0010576 enzyme regulator activity • metal ion binding • hydrolase activity Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • extracellular region Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • positive regulation of triglyceride biosynthetic process • positive regulation of ATP-dependent activity • negative regulation of protein kinase activity • kidney development • negative regulation of flagellated sperm motility • GO:0010260 heneiddio • positive regulation of proteolysis involved in cellular protein catabolic process • cellular calcium ion homeostasis • negative regulation of apoptotic process • positive regulation of glucose metabolic process • positive regulation of fatty acid biosynthetic process • negative regulation of bone development • positive regulation of dUTP diphosphatase activity • positive regulation of phosphatase activity • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • liver regeneration • GO:0034259 negative regulation of GTPase activity • negative regulation of nitric oxide biosynthetic process • negative regulation of RNA biosynthetic process • spermatogenesis • regulation of calcium-mediated signaling • negative regulation of epithelial cell proliferation • negative regulation of leucine-tRNA ligase activity • negative regulation of phosphoprotein phosphatase activity • liver development • negative regulation of cyclic-nucleotide phosphodiesterase activity • negative regulation of DNA catabolic process • negative regulation of DNA biosynthetic process • positive regulation of ATPase-coupled calcium transmembrane transporter activity • negative regulation of calcium-dependent ATPase activity • positive regulation of superoxide dismutase activity • L-ascorbic acid biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9104	n/a
Ensembl	ENSG00000130988	n/a
UniProt	Q15493	n/a
RefSeq (mRNA)	NM_001282848 NM_001282849 NM_004683 NM_152869	n/a
RefSeq (protein)	NP_001269777 NP_001269778 NP_004674 NP_690608	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RGN.

• RC
• GNL
• SMP30
• HEL-S-41

Llyfryddiaeth

• "Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro. ". Int J Oncol. 2016. PMID 27221776.
• "Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro. ". Int J Oncol. 2016. PMID 26935290.
• "Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro. ". Mol Cell Biochem. 2017. PMID 28181135.
• "Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro. ". Int J Oncol. 2016. PMID 27633001.
• "The Emerging Role of Regucalcin as a Tumor Suppressor: Facts and Views.". Curr Mol Med. 2016. PMID 27411833.