RHOA

RHOA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	5BWM, 1A2B, 1CC0, 1CXZ, 1DPF, 1FTN, 1KMQ, 1LB1, 1OW3, 1S1C, 1TX4, 1X86, 1XCG, 2RGN, 3KZ1, 3LW8, 3LWN, 3LXR, 3MSX, 3T06, 4D0N, 4XH9, 4XSG, 4XSH, 4XOI, 5A0F, 5FR2, 5FR1, 5JCP, 5C2K, 5C4M, 5HPY
Dynodwyr
Cyfenwau	RHOA, ARH12, ARHA, RHO12, RHOH12, ras homolog family member A, EDFAOB
Dynodwyr allanol	OMIM: 165390 HomoloGene: 68986 GeneCards: RHOA
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • myosin binding; • GTP binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • GDP binding; • protein kinase binding; • protein domain specific binding; • Rho GDP-dissociation inhibitor binding;
Cydrannau o'r gell	• cytoplasm; • fesigl; • cytosol; • endosome; • cell projection; • endoplasmic reticulum membrane; • bilen; • focal adhesion; • extrinsic component of cytoplasmic side of plasma membrane; • Cellbilen; • cell junction; • cell cortex; • midbody; • cleavage furrow; • Cytosgerbwd; • apical junction complex; • extracellular exosome; • cyrion cell; • lamellipodium; • secretory granule membrane; • ficolin-1-rich granule membrane; • cnewyllyn cell; • axon; • cell division site; • ruffle membrane; • dendritic spine; • intracellular membrane-bounded organelle; • postsynapse; • glutamatergic synapse; • intracellular anatomical structure;
Prosesau biolegol	• actin cytoskeleton reorganization; • ossification involved in bone maturation; • apolipoprotein A-I-mediated signaling pathway; • regulation of cell migration; • negative chemotaxis; • regulation of actin cytoskeleton organization; • cleavage furrow formation; • substantia nigra development; • ephrin receptor signaling pathway; • endothelial tube lumen extension; • Roundabout signaling pathway; • positive regulation of axonogenesis; • stress fiber assembly; • positive regulation of lipase activity; • regulation of osteoblast proliferation; • Cellraniad; • positive regulation of cytokinesis; • platelet activation; • negative regulation of cell migration involved in sprouting angiogenesis; • positive regulation of protein serine/threonine kinase activity; • mitotic cleavage furrow formation; • mitotic spindle assembly; • negative regulation of axonogenesis; • vascular endothelial growth factor receptor signaling pathway; • skeletal muscle satellite cell migration; • trabecula morphogenesis; • positive regulation of neuron differentiation; • Rho protein signal transduction; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • cell cycle; • GO:0022415 viral process; • regulation of small GTPase mediated signal transduction; • transforming growth factor beta receptor signaling pathway; • cell migration; • apical junction assembly; • wound healing, spreading of cells; • endothelial cell migration; • positive regulation of stress fiber assembly; • actin cytoskeleton organization; • phosphatidylinositol-mediated signaling; • small GTPase mediated signal transduction; • regulation of cell motility; • Wnt signaling pathway, planar cell polarity pathway; • protein deubiquitination; • neutrophil degranulation; • GO:0000767 cell morphogenesis; • response to hypoxia; • angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure; • alpha-beta T cell lineage commitment; • regulation of systemic arterial blood pressure by endothelin; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • cytoskeleton organization; • actin filament organization; • cell adhesion; • cell-matrix adhesion; • G protein-coupled receptor signaling pathway; • skeletal muscle tissue development; • regulation of actin polymerization or depolymerization; • regulation of cell shape; • response to mechanical stimulus; • response to glucose; • negative regulation of cell-substrate adhesion; • regulation of neuron projection development; • negative regulation of neuron projection development; • cerebral cortex cell migration; • forebrain radial glial cell differentiation; • cell differentiation; • positive regulation of cell growth; • positive regulation of cell migration; • androgen receptor signaling pathway; • positive regulation of actin filament polymerization; • establishment or maintenance of actin cytoskeleton polarity; • stress-activated protein kinase signaling cascade; • negative regulation of intracellular steroid hormone receptor signaling pathway; • cell junction assembly; • odontogenesis; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • response to amino acid; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • beta selection; • GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of neuron apoptotic process; • establishment of epithelial cell apical/basal polarity; • response to ethanol; • negative regulation of neuron differentiation; • positive regulation of translation; • positive regulation of cell adhesion; • negative regulation of cell size; • positive regulation of vasoconstriction; • positive regulation of smooth muscle contraction; • GTP metabolic process; • positive regulation of alpha-beta T cell differentiation; • neuron projection morphogenesis; • regulation of dendrite development; • actin filament bundle assembly; • response to glucocorticoid; • regulation of focal adhesion assembly; • regulation of calcium ion transport; • negative regulation of cell death; • regulation of microtubule cytoskeleton organization; • cellular response to lipopolysaccharide; • cellular response to cytokine stimulus; • positive regulation of podosome assembly; • negative regulation of oxidative phosphorylation; • positive regulation of NIK/NF-kappaB signaling; • negative regulation of reactive oxygen species biosynthetic process; • positive regulation of vascular associated smooth muscle contraction; • positive regulation of leukocyte adhesion to vascular endothelial cell; • regulation of modification of synaptic structure; • regulation of modification of postsynaptic actin cytoskeleton; • cellular response to chemokine; • regulation of neural precursor cell proliferation; • positive regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologau
	387
	n/a
	ENSG00000067560
	n/a
	P61586
	n/a
NM_001313941; NM_001313943; NM_001313944; NM_001313945; NM_001313946;
	NM_001313947; NM_001664
	n/a
NP_001300870; NP_001300872; NP_001300873; NP_001300874; NP_001300875;
	NP_001300876; NP_001655; NP_001300870.1; NP_001655.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RHOA yw RHOA a elwir hefyd yn Transforming protein RhoA (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RHOA.

ARHA
ARH12
RHO12
RHOH12

Llyfryddiaeth

"The effect of Rho drugs on mast cell activation and degranulation. ". J Leukoc Biol. 2017. PMID 28411215.
"RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells. ". J Cell Sci. 2017. PMID 28089989.
"Variegated RHOA mutations in human cancers. ". Exp Hematol. 2016. PMID 27693615.
"Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas. ". Blood. 2016. PMID 27369867.
"[Increased apoptosis and down-regulation of RhoA in HepG2 cells infected by Listeria monocytogenes].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016. PMID 27126939.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RHOA - Cronfa NCBI

[2]

[1]