RNF2

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNF2 yw RNF2 a elwir hefyd yn E3 ubiquitin-protein ligase RING2 a Ring finger protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q25.3.

RNF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H0D, 3GS2, 3H8H, 3IXS, 3RPG, 4R8P, 4S3O
Dynodwyr
Cyfenwau	RNF2, BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2, ring1B, LUSYAM
Dynodwyr allanol	OMIM: 608985 HomoloGene: 2199 GeneCards: RNF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • chromatin binding • RING-like zinc finger domain binding • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • transferase activity • zinc ion binding Cydrannau o'r gell • GO:0035327 euchromatin • sex chromatin • ubiquitin ligase complex • nucleoplasm • Cromosom • GO:0035328 heterochromatin • MLL1 complex • PRC1 complex • PcG protein complex • cnewyllyn cell • nuclear body Prosesau biolegol • germ cell development • histone H2A-K119 monoubiquitination • GO:0009373 regulation of transcription, DNA-templated • gastrulation with mouth forming second • histone H2A monoubiquitination • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • protein ubiquitination • GO:0007067 Mitosis • anterior/posterior axis specification • histone ubiquitination • negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6045	n/a
Ensembl	ENSG00000121481	n/a
UniProt	Q99496	n/a
RefSeq (mRNA)	NM_007212	n/a
RefSeq (protein)	NP_009143	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNF2.

• BAP1
• DING
• BAP-1
• HIPI3
• RING2
• RING1B

Llyfryddiaeth

• "Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions. ". Cell Rep. 2014. PMID 24813883.
• "[Effect of RNF2 knockdown on apoptosis and radiosensitivity in glioma U87 cells]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014. PMID 24796740.
• "Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression. ". Int J Oncol. 2016. PMID 26936624.
• "Overexpression of RNF2 Is an Independent Predictor of Outcome in Patients with Urothelial Carcinoma of the Bladder Undergoing Radical Cystectomy. ". Sci Rep. 2016. PMID 26869491.
• "RING1B O-GlcNAcylation regulates gene targeting of polycomb repressive complex 1 in human embryonic stem cells.". Stem Cell Res. 2015. PMID 26100231.